膝骨关节炎表观遗传学研究进展
Advances on the epigenetics of knee osteoarthritis
徐斌丰 1宋月莹 1吴海君 1郑程2
作者信息
- 1. 311400 浙江省,杭州市富阳区鹿山街道社区卫生服务中心医疗康复科
- 2. 310051 杭州,浙江康复医疗中心骨伤康复科
- 折叠
Abstract
Knee osteoarthritis is a complex genetic joint disease,and epigenetic factors play an important role in its development.The mechanisms of epigenetic regulation mainly include DNA modification,histone posttranslational modifications and non-coding RNA regulation.Epigenetic traits are cell-and tissue-specific and can vary with the environment.Unraveling of their roles in human tissues are particularly difficult.As the lowered threshold for gene sequencing,some epigenomic studies have summarized and improved epigenetic models and elucidated the mechanisms of the actions between epigenetic factors and knee osteoarthritis,which could help to understand the disease and develop new epigenetic-based therapeutic targets.This review reviews the progress of epigenetics in knee osteoarthritis.
关键词
骨关节炎,膝/表观基因组学/DNA甲基化/RNA,未翻译/组蛋白修饰/综述Key words
Osteoarthritis,knee/Epigenomics/DNA methylation/RNA,untranslated/Histone modifications/Review引用本文复制引用
出版年
2024
NETL
NSTL
维普
万方数据