Clinical efficacy of platelet-rich plasma on frozen shoulder:a systematic review and Meta-analysis of randomized controlled trials
Objective To systematically review the clinical efficacy and safety of platelet-rich plasma(PRP)in the treatment of frozen shoulder,and provide evidence-based medical evidence for the effectiveness of PRP in the treatment of frozen shoulder.Methods Domestic and foreign databases were searched for clinical research regarding platelet-rich plasma for the treatment of frozen shoulder(adhesive capsulitis/periarthritis/fifty shoulder)published from inception to September 2022.Literatures were strictly screened,and data were input into RevMan5.4 for meta-analysis.Results Ten RCTs were included,with a total of 717 patients.The results showed that VAS[MD =-0.51,95%CI(-0.88,-0.14),P = 0.007],UCLA[MD = 3.31,95%CI(1.02,5.60),P = 0.005],SPADI[SPADI Total:MD =-17.33,95%CI(-29.80,-4.85),P = 0.006;SPADI Pain:MD =-5.09,95%CI(-10.17,-0.01),P = 0.05;SPADI Disability:MD =-9.59,95%CI(-15.39,-3.79),P = 0.001]and active and passive motion of shoulder joint in all directions[active flexion:MD = 12.70,95%CI(7.44,17.95),P＜0.000 01;passive flexion:MD = 9.47,95%CI(3.80,15.14),P = 0.001;active extension:MD = 3.45,95%CI(2.39,4.50),P＜0.000 01;active abduction:MD = 13.54,95%CI(8.42,18.66),P＜0.000 01;passive abduction:MD = 14.26,95%CI(5.97,22.56),P = 0.0008;active internal rotation:MD = 5.16,95%CI(1.84,8.48),P = 0.002;passive internal rotation:MD = 3.65,95%CI(1.15,6.15),P = 0.004;active external rotation:MD = 10.50,95%CI(5.47,15.53),P＜0.0001;passive external rotation:MD = 6.00,95%CI(1.82,10.19),P = 0.005]except passive extension[MD = 2.25,95%CI(-0.77,5.28),P = 0.14]after PRP treatment had significant advantages compared with the control group.After treatment,there was no statistically significant difference of DASH in platelet-rich plasma group compared with control group[MD =-3,86,95%CI(-7.79,0.07),P = 0.05].Conclusions PRP is more durable and effective than corticosteroids and other control groups in the treatment of frozen shoulders.
NETL
NSTL
万方数据
维普
