Clinical characterization and prognostic study of multicenter traumatic osteomyelitis of the extremities
Objective To explore the clinical characteristics and prognostic factors of patients with traumatic osteomyelitis of the extremities in Shanxi region by a multicenter analysis.Methods All data were from four hospitals,including the Second Hospital of Shanxi Medical University,Provincial People's Hospital,Baiqiuen Hospital,and Yuncheng Central Hospital.Basic information,laboratory indexes,and pathogenic bacteria culture results of patients diagnosed as traumatic osteomyelitis from January 1,2016 to December 31,2021 were retrospectively collected.All were divided into good prognosis group and poor prognosis group according to the discharge status.The comparison between the two groups was performed by χ2 or Mann-Whitney U test with multivariate logistic regression model to analyze the prognostic influencing factors.Results The median age of onset was 47 years(range:33-58 years);More open fractures(241,64.4%)were observed;(150,40.1%)were caused by traffic injury;tibiae was the prevalent site of infection(201,53.7%);the positive rates of serum inflammatory markers were 18.7%for leukocytes,62.1%for C-reactive protein,and 75.0%for erythrocyte sedimentation rate;the positive rate of pathogenic bacteria culture was 69.8%,and single pathogenic bacteria accounted for 145 cases(73.2%),with staphylococcus aureus 73 cases(50.3%)being the most common.Multiple logistic regression showed that CRP(OR = 0.965,95%CI 0.924-0.989)was a prognostic factor for traumatic osteomyelitis of the extremities.Conclusions Traumatic osteomyelitis of the extremities is mostly seen in men,secondary to open fractures,preferably in the tibia,and with Staphylococcus aureus as the common causative agent.CPR is a prognostic factor for traumatic osteomyelitis of the extremities.
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