首页|circRNA经由ceRNA机制调控BMSCs成骨分化在股骨头坏死中的研究进展

circRNA经由ceRNA机制调控BMSCs成骨分化在股骨头坏死中的研究进展

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circRNA regulates osteogenic differentiation of bone marrow mesenchymal stem cells via ceRNA mechanism in osteonecrosis of the femoral head
Osteonecrosis of the femoral head(ONFH)is one of the common diseases in orthopedics.The disease has complex pathogenic factors and high disability rate,which can eventually lead to structural changes of the femoral head,collapse of the femoral head,and hip joint dysfunction.With the development of high-throughput sequencing technology,many studies have shown that circular RNA(cirRNA)can regulate the osteogenesis and differentiation of bone marrow mesenchymal stem cells(BMSCs)through competing endogenous RNA(ceRNA)mechanism,and affect the occurrence and development of ONFH.In addition,circRNA is expected to become an ONFH diagnostic biomarker and participates in ONFH precision medicine as a therapeutic target.In this review,circRNA regulates osteogenic differentiation of BMSCs through ceRNA mechanism,and we discuss the role of this process in ONFH,in order to provide a new idea for diagnosis and treatment of ONFH.

RNA,circularMesenchymal stem cellsFemur head necrosisCompeting endogenous RNAReview

柳可心、刘凯、冬梅、王建忠

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010030 呼和浩特,内蒙古医科大学

010030 呼和浩特,内蒙古医科大学第二附属医院骨质疏松科

010030 呼和浩特,内蒙古医科大学第二附属医院创伤外科中心C区

RNA,环状 间质干细胞 股骨头坏死 竞争性内源 RNA 综述

国家自然科学基金内蒙古自治区硕士研究生科研创新项目内蒙古医科大学大学生创新创业训练计划内蒙古医科大学"致远"人才计划内蒙古自治区科技计划

81860401S20231189ZS202310132019XZY1100182022YFSH0075

2024

10.3969/j.issn.2095-252X.2024.03.010

中国骨与关节杂志
中国医疗保健国际交流促进会，北京中科康辰骨关节伤病研究所

中国骨与关节杂志

CSTPCD
影响因子：0.665
ISSN：2095-252X
年,卷(期)：2024.13(3)
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