circRNA经由ceRNA机制调控BMSCs成骨分化在股骨头坏死中的研究进展
circRNA regulates osteogenic differentiation of bone marrow mesenchymal stem cells via ceRNA mechanism in osteonecrosis of the femoral head
柳可心 1刘凯 1冬梅 2王建忠3
作者信息
- 1. 010030 呼和浩特,内蒙古医科大学
- 2. 010030 呼和浩特,内蒙古医科大学第二附属医院骨质疏松科
- 3. 010030 呼和浩特,内蒙古医科大学第二附属医院创伤外科中心C区
- 折叠
Abstract
Osteonecrosis of the femoral head(ONFH)is one of the common diseases in orthopedics.The disease has complex pathogenic factors and high disability rate,which can eventually lead to structural changes of the femoral head,collapse of the femoral head,and hip joint dysfunction.With the development of high-throughput sequencing technology,many studies have shown that circular RNA(cirRNA)can regulate the osteogenesis and differentiation of bone marrow mesenchymal stem cells(BMSCs)through competing endogenous RNA(ceRNA)mechanism,and affect the occurrence and development of ONFH.In addition,circRNA is expected to become an ONFH diagnostic biomarker and participates in ONFH precision medicine as a therapeutic target.In this review,circRNA regulates osteogenic differentiation of BMSCs through ceRNA mechanism,and we discuss the role of this process in ONFH,in order to provide a new idea for diagnosis and treatment of ONFH.
关键词
RNA,环状/间质干细胞/股骨头坏死/竞争性内源/RNA/综述Key words
RNA,circular/Mesenchymal stem cells/Femur head necrosis/Competing endogenous RNA/Review引用本文复制引用
基金项目
国家自然科学基金(81860401)
内蒙古自治区硕士研究生科研创新项目(S20231189Z)
内蒙古医科大学大学生创新创业训练计划(S202310132019X)
内蒙古医科大学"致远"人才计划(ZY110018)
内蒙古自治区科技计划(2022YFSH0075)
出版年
2024
NETL
NSTL
万方数据