免疫系统在不同类型骨质疏松症的作用研究进展
Research progress on the role of immune system in different types of osteoporosis
李朝霞 1张晓峰 1徐西林 2刘江燕1
作者信息
- 1. 150006 哈尔滨,黑龙江中医药大学
- 2. 150036 哈尔滨,黑龙江中医药大学附属第二医院骨科
- 折叠
Abstract
Classical theories suggest that osteoporosis is essentially a disorder of bone remodeling caused by estrogen deficiency,primary osteoporosis of aging,or secondary osteoporosis to diseases and drugs.However,in recent years,advances in the understanding of the complex link between bone and the immune system have led Srivastava et al.to introduce the new term"immunoarporosis"to describe the growing importance of immune cells in osteoporosis.In postmenopausal osteoporosis,immune cell changes mediated by estrogen deficiency stimulate osteoclast activation to varying degrees.In senile osteoporosis,aging causes persistent activation of the immune system at a low level,which disrupts the immune balance and ultimately leads to bone loss.In diabetic osteoporosis,hyperglycemia caused by insulin deficiency or resistance may lead to abnormal regulation of immune cells and excessive production of pro-inflammatory factors leading to osteoporosis.Therefore,this article reviews the relationship between immune cells and three kinds of osteoporosis,in order to provide new therapeutic targets for different osteoporosis.
关键词
免疫,细胞/细胞因子类/骨质疏松,绝经后/老年人/糖尿病/综述Key words
Immunity,cellular/Cytokines/Osteoporosis,postmenopausal/Aged/Diabetes mellitus/Review引用本文复制引用
基金项目
国家自然科学基金(81904222)
黑龙江省重点研发计划(GZ20210)
全国名老中医药专家传承工作室建设项目(2022)(2021-2024)
出版年
2024
NETL
NSTL
万方数据