Risk factors for recurrence and regrowth of spinal schwannoma
Objective To evaluate the risk factors for recurrence and regrowth of spinal neurilemmoma,further provide references for clinical diagnosis and treatment.Methods A retrospective analysis was conducted on the clinical data of 65 patients who underwent spinal cord schwannoma resection in our hospital from January 2020 to January 2022.Patients with postoperative recurrence or residual tumor regeneration>10%(R+group)were compared with those without recurrence or regeneration(R-group).Multiple logistic regression analysis was used to investigate the impact of risk factors on recurrence and regeneration.Results The average follow-up time of 65 patients was 24 months,involving cervical vertebrae(14 cases),thoracic vertebrae(25 cases),and lumbar vertebrae(26 cases);65%located within the dura mater,17%located outside the dura mater,and 18%located inside the dura mater.Postoperative recurrence occurred in 4 cases(6.2%),and regrowth occurred in 7 cases(10.8%).Univariate analysis showed significant differences between the R+group(11 cases)and the R-group(54 cases)in Sridhar tumor classification,giant tumor(Sridhar grade Ⅱ,Ⅳb,and Ⅴ),left and posterior cranial tumor size,maximum diameter,surgical time,bleeding volume,subtotal resection,reoperation,fusion surgery,and follow-up time.Multivariate logistic regression analysis showed that giant tumor(Sridhar classification Ⅱ,Ⅳb,and Ⅴ types)was the independent risk factor for recurrence and regrowth.Conclusions The recurrence and regeneration rate of spinal schwannoma is approximately 16.9%within 2 years.Giant tumor(Sridhar classification Ⅱ,Ⅳb,and Ⅴ types)is the independent risk factor for recurrence and regeneration,which is worthy of clinical attention.
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