Research progress of miR-26a on metastasis and treatment of osteosarcoma
Osteosarcoma represents the most common form of bone malignant tumor with strong aggressiveness,easy metastasis,and chemotherapy resistance.The pathogenesis of osteosarcoma is yet to be fully elucidated.MicroRNAs are classified as noncoding small RNA with a length of 20-22 nucleotides,which are abnormally expressed in a variety of malignant tumors.miR-26a is an important member of the MicroRNA family,and its expression has been found to be associated with the occurrence,development,invasion,metastasis and drug resistance of osteosarcoma.Mechanism of miR-26a in osteosarcoma has important clinical significance for the diagnosis,treatment and prognosis of osteosarcoma.This article reviews the effects of miR-26a on the occurrence,development,invasion,metastasis and drug resistance of osteosarcoma,which provides a reference for the diagnosis and prediction of osteosarcoma.
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