Analysis of the correlation between the medication regimen complexity index and prognosis in elderly patients with lumbar degenerative diseases
Objective To evaluate the correlation of the complexity of admission pharmacological regimens with postoperative complications and length of hospitalization in elderly patients with lumbar degenerative disease(LDD)treated with lumbar fusion.Methods A retrospective analysis of 130 LDD elderly patients treated with lumbar fusion from January 2019 to January 2023 in our hospital was conducted.Admission medication regimen complexity was evaluated by the medication regimen complexity index(MRCI).Postoperative complications and postoperative length of stay(PLOS)were recorded.Pearson test was used to assess the correlation between MRCI score and PLOS.Results Of the 130 patients,32(24.6%)developed postoperative complications,with urinary tract infection being the most common followed by pneumonia and deep vein thrombosis.PLOS was(11.11±6.37)days,P75(75th percentile value)=15 days,and 36(27.7%)patients had prolonged PLOS.The total MRCI score was(7.62±2.80).The AUC of MRCI score of part A,part B,part C and total score predicting postoperative complications were 0.609(0.520-0.694),0.743(0.659-0.816),0.698(0.612-0.776),0.741(0.657-0.814)respectively;the AUC predicting prolonged PLOS was 0.824(0.747-0.885),0.851(0.778-0.9071),0.849(0.776-0.906),and 0.960(0.910-0.986),respectively.The total MRCI score was an independent risk factor for postoperative complications and prolonged PLOS(P<0.05).Conclusions Elderly patients with LDD have a higher incidence of postoperative complications and longer PLOS.Further evaluation of the complexity of drug regimens can be beneficial in improving prognosis and reducing the cost of diagnosis and treatment.
AgedLumbar vertebraeSpinal fusionLength of stayPostoperative complications
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