骨肉瘤免疫微环境机制及免疫治疗的研究进展
Research progress on the mechanisms of the tumor immune microenvironment and immunotherapy in osteosarcoma
郭超凡 1李利军1
作者信息
- 1. 030012 太原,山西省人民医院(山西医科大学第五临床医学院)骨科
- 折叠
Abstract
Osteosarcoma is a rare but deadly group of malignant tumors,including multiple subtypes and complex biological characteristics.The role of immune microenvironment of these tumors is gradually receiving attention and is considered as a key factor affecting treatment response and prognosis.This review paper aims to delve into the mechanisms of the immune microenvironment in osteosarcoma and the research progress of immunotherapy in this field.We first summarized the basic biology of the immune microenvironment of osteosarcoma,especially the role of T cells,macrophages,and other immune cells in the tumor microenvironment.Next,we reviewed the current immunotherapy strategies,including immune checkpoint inhibitors and immune cell therapy,as well as their applications and limitations in osteosarcoma.Although the immune microenvironment of osteosarcoma is complex and challenging,understanding its underlying mechanisms is expected to provide theoretical basis for developing more effective immunotherapy.
关键词
骨肉瘤/免疫疗法/肿瘤微环境/抗肿瘤药,免疫/综述Key words
Osteosarcoma/Immunotherapy/Tumor Microenvironment/Antineoplastic agents,immunological/Review引用本文复制引用
基金项目
山西省科技创新人才团队(202204051002035)
出版年
2024
NETL
NSTL
万方数据