Research progress of endoplasmic reticulum stress and its role in osteosarcoma
Endoplasmic reticulum(ER)is a key organelle for cell function and metabolic adaptation.Disrupted ER homeostasis,including hypoxia,insufficient amino acid supply and lactic acidosis,will lead to ER stress(ERS),further unfolded protein response(UPR),ER associated protein degradation(ERAD),activation of autophagy pathway and other abnormal reactions,resulting in metabolic disorders of some important proteins in the body.It has been confirmed that ERS is involved in the pathogenesis of diabetes,breast cancer,lung cancer,prostate cancer and other diseases.Reganding the role of ERS in osteosarcoma,there are some latest research results at home and abroad.In this paper,we reviewed the mechanisms of endoplasmic reticulum stress and related signaling pathways targeting Ca2+,reactive oxygen species(ROS),epithelial mesenchymal transformation(EMT),ncRNA,etc.,in order to provide new ideas for future research and treatment strategies of osteosarcoma.
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