The role of adenosine receptors in osteoarthritis:a review
Osteoarthritis(OA)is the most common degenerative joint disease,with synovial inflammation and articular cartilage degeneration as primary manifestations.Adenosine is an endogenous purine nucleoside that typically binds to its transmembrane G protein coupled receptors(ADORA1,ADORA2A,ADORA2B,ADORA3)to exert physiological effects.Adenosine receptor-mediated signals are widely involved in physiological processes such as inflammatory responses,and their expression levels or activation states change with the progression of OA,which suggests that adenosine receptors hold promise as targets for OA therapy.Therefore,we summarize the role of the four adenosine receptors in OA and the main methods of regulation of them in this review,with a view to provide references for subsequent research efforts on novel targets for intervention in the course of OA.
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