Cellular phenotypes and mechanisms in osteonecrosis of the femoral head:a review
Recent focus on basic research into femoral head osteonecrosis(ONFH)has unveiled the significance of various cells in disease onset,progression,and treatment.These include osteoblasts and osteoclasts for bone homeostasis,endothelial cells for new blood vessel formation,and macrophages for immune responses.Cell phenotypes,indicative of changes when cells are influenced by disease-specific molecules,are fundamental for molecular function analysis.Research has commonly explored phenotypes like cell growth,death,and movement,with growing interest in macrophage polarization and iron-induced cell death.This review encapsulates the key cellular players and their phenotypes in ONFH research,guiding future directions in the disease mechanism studies.
万方数据
维普
