Abstract
Bone defects caused by trauma,infection,tumor,and congenital malformation are difficult to heal naturally,which usually require clinical intervention.Autologous bone transplantation is the"gold standard"in clinical treatment of bone defects,but it faces the shortcomings of limited donors.Bone tissue engineering has brought new hope for bone defect repair.In order to develop bone tissue engineering materials that meet clinical needs,it is necessary to simulate biological signals and bone structure.In this paper,the osteogenic mechanism and bone structure of bone tissue regeneration are reviewed,which will provide help and inspiration for the design of bone tissue engineering biomaterials.
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