The Yangtze River Basin is an important industrial and agricultural production area and ecological security barrier in China.In-depth research on the spatial-temporal evolution of vegetation in the basin and its influencing factors and scale effects is of great significance for understanding the regional vegetation growth under changing environments and grasping the ecological environment quality.However,previous studies have not fully considered the difference between/in scale effects of different influencing factors of vegetation spatial differentiation pattern.Therefore,this study took the vegetation coverage of the Yangtze River Basin from 2000 to 2022 as the dependent variable and used terrain,meteorology,and socio-economic factors as independent variables.With the help of multiscale geographic weighted regression(MGWR)which was good at handling scale differences,the spatial-temporal changes of vegetation and its influencing factors were explored.The results showed that:1)Vegetation coverage in the Yangtze River Basin fluctuated between 2000 and 2022,with an overall improvement trend and a growth rate of 0.245%per year.The spatial distribution pattern of vegetation in the basin showed a low-east and high-central pattern,indicating significant spatial differentiation.However,there was a risk of degradation in most areas of the basin in the future.2)Different influencing factors had obvious spatial differences in their effects on vegetation in the Yangtze River,among which slope,elevation,temperature,and relative humidity were the main driving factors.It was noteworthy that anthropogenic factors had relatively small influence on vegetation.3)The response scales of vegetation to various influencing factors were significantly different,with natural factors such as terrain and climate having smaller impact scales(only 43)than social factors(over 870).