Effects of triclosan and bisphenol A on zebrafish neurotoxicity
In this research,two typical environmental endocrine disruptors,triclosan(TCS)and bisphenol A(BPA)were selected as target chemicals and zebrafish(Danio rerio)were used as vertebrate model organisms.The effects of TCS and BPA on zebrafish neurodevelopment and locomotor behavior were investigated in detail.Results showed that both TCS and BPA induced phenotypic malformations in zebrafish embryos,such as pericardial edema,yolk cysts and swiming sac closure.Besides,their exposure inhibited the locomotor activity,damaged motor-related neurons and affected the activity of acetylcholinesterase in larval zebrafish,resulting in neurobehavioral disorders.Moreover,TCS and BPA both led to a decrease in the number of neonatal neuronal cells and an increase in apoptotic cells in zebrafish brain,which had a severe impact on the development of central nervous system.Target prediction combined with Kyoto Encyclopedia of Genes and Genomes(KEGG)and Gene Ontology(GO)cluster analysis was used to compare the similarities and differences between the metabolic pathways of TCS and BPA,as well as their underlying toxicity mechanisms.These findings provide an important theroretical reference for risk assessment and early waming of environmental exposure to TCS and BPA.
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维普
