Toxic effects and comparison of PFOS and its three alternatives on earthworms
The toxic effects of PFOS,6∶2 FTSA,PFHxS,and PFBS on Eisenia fetida were investigated in terms of oxidative stress,reproductive toxicity,and developmental toxicity after 28 days of exposure to the same concentration(0.2mg/kg).PFOS,6∶2 FTSA,PFHxS,and PFBS all caused an increase in ROS content and led to lipid peroxidation and DNA damage.In addition,PFOS and its three alternatives also induced abnormal gene expression related to oxidative stress,reproduction,and growth and development.Thus inducing oxidative stress and triggering reproductive toxicity,and developmental toxicity at the genetic level.The results of integrated biomarker response(IBR)index showed that the IBR values of PFOS,6∶2 FTSA,PFHxS and PFBS were 36.4,22.2,34.1,and 24.3,respectively.The combined toxicity of the four substances to earthworms was in the following order∶PFOS＞PFHxS＞PFBS＞6∶2 FTSA,which indicated that the combined toxicity of the three alternatives was lower than that of the PFOS.The results of this study provided a basis for the safety evaluation of 6∶2 FTSA,PFHxS,and PFBS as alternatives to PFOS.
万方数据
维普
