Correlation analysis of mixed metal exposure and early renal function impairment indicators in a mining area
In order to reveal the current status of cadmium,copper,manganese,molybdenum,chromium,aluminum,cobalt,vanadium,lead,arsenic,zinc,and nickel exposure in a mining area,and to analyze the association between mixed metal exposure and urinary β2-microglobulin(β2-MG)and N-acetyl-β-D-aminoglucosidase(NAG),which are indicators of early renal impairment,636residents of the mining area were selected according to stratified whole-group sampling,and urinary β2-MG and NAG levels were measured by ICP-MS.The urinary metal concentrations were measured by ICP-MS,and the urinary β2-MG and NAG levels were determined by latex immunoturbidimetric and colorimetric methods,respectively.The combined effect of mixed metal exposure on urinary β2-MG and NAG was then evaluated using a weighted quantile and regression(WQS regression)model with the weights of individual metals.The results showed that the distribution of urinary metal levels varied widely for cadmium,molybdenum,copper,aluminum,zinc,and vanadium;the distribution of urinary β2-MG ranged from 0.19(0.14,0.29)mg/L;the distribution of urinary NAG ranged from 7.00(3.30,11.90)U/L;the WQS regression results showed that the metal WQS index was associated with an increased risk of abnormal urinary β2-MG and an abnormal risk of abnormal urinary NAG reduced risk of urinary NAG abnormalities.The metals with the highest WQS index weights that increased the risk of urinary β2-MG abnormalities were copper 0.493,chromium 0.120,and cadmium 0.116.The metals with relatively high weights in different age groups included molybdenum,manganese,and zinc(＜60years old group);and copper,cadmium,and molybdenum(≥60years old group).The metals with the highest WQS index weights to reduce the risk of urinary NAG abnormalities were zinc 0.328,molybdenum 0.167,chromium 0.144,nickel 0.138,and manganese 0.108.The metals with relatively high weights in different age groups included aluminum,molybdenum,and zinc(＜60years group);and cobalt,chromium,and molybdenum(≥60years group).Therefore,the distribution of urinary cadmium,molybdenum,copper,aluminum,zinc,and vanadium levels in this mining population was in the middle to upper range.There was an association between exposure to mixed metals and increased risk of urinary β2-MG abnormalities and decreased risk of urinary NAG abnormalities.The metals causing higher weights of β2-MG abnormalities were copper,chromium,and cadmium,and the metals reducing higher weights of NAG abnormalities were zinc,molybdenum,chromium,nickel,and manganese.
mixed metalsindicators of early renal function impairmentcorrelationWeighted Quantile Sum Regression
万方数据
维普
