Dietary risk assessment based on the probability distribution of fluopyram residues
The exposure risk of fluopyram in cucumber was comprehensively evaluated for different dietary consumption groups in China based on its residual characteristics.A rapid and sensitive ultra performance liquid chromatography-tandem mass spectrometry method was developed for the determination of fluopicolide in cucumber,with limit of quantitation(LOQ)of 0.001 mg/kg and retention time of 2.6 min.The half-lives of fluopyram in cucumber was 2.6～6.7d,indicated it was an easily digestible pesticide.The final levels of fluopyram was＜LOQ～0.130mg/kg,which were lower than the maximum residue limit standard of China and the world.Probabilistic and deterministic models showed that fluopyram did not pose an unacceptable short-term dietary risk to Chinese dietary consumers(％ARfD,0.081％～2.527％),whereas there was an unacceptable long-term dietary risk(％ADI,105.740％～528.147％),of which cucumber accounted for 0.325％～1.107％.In addition,the long-term dietary risks of children aged 2～6 years(367.156％～528.147％)were significantly higher than that of other age groups(334.940％～105.740％)(p＜0.05).In summary,we should further focus on the negative effects of fluopyram exposure under multiple exposure pathways and joint risk amplification in the follow-up study,especially for vulnerable children.
万方数据
维普
