首页|Two unique C21-diterpenoid alkaloids from Aconitum carmichaelii
Two unique C21-diterpenoid alkaloids from Aconitum carmichaelii
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Two sulfonated diterpenoid alkaloids possessing different but related novel carbon skeletons,named aconidenusulfonine A(1)and 12,16-secoaconidenusulfonine A(2),respectively,were isolated as minor components from an aqueous extract of the lateral roots of Aconitum carmichaelii("Fu Zi").The struc-tures of 1 and 2,representing the first two C21-diterpenoid alkaloids from nature,were determined by analysis of various spectroscopic data and chemical transformation,of which 1 was further proved by single-crystal X-ray diffraction.Especially,1 exhibited dose-depended analgesic activity consistent with the clinical function of Fu Zi.
Jingfang Zhang、Xiaoqiang Lei、Yazi Wei、Hui Liu、Qinglan Guo、Tiantai Zhang、Jiangong Shi
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State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China
国家自然科学基金国家自然科学基金CAMS Innovation Fund for Medical Science
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