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中国化学快报（英文版）
中国化学快报（英文版）

梁晓天

月刊

1001-8417

cclbj@imm.ac.cn

010-63165638

100050

北京市先农坛街1号

中国化学快报（英文版）/Journal Chinese Chemical LettersCSCDCSTPCD北大核心SCI
查看更多>>本刊是由中国科协主管、中国化学会主办、中国医学科学院药物所承办的学术期刊，是由著名化学家梁晓天院士主编。是中国化学界通向世界的窗口，内容覆盖化学全领域。本刊的办刊宗旨是“新、快、准”，我们将坚持这个宗旨，力求及时反映化学研究中各个相关领域内的最新进展及热点问题，主要读者群是科研人员、研究生、大学教师。现已被国内外多家数据库收录，如SCI　Search、Chemical Abstract、Research Alert、Chemistry Citation Index、《日本科技文献速报》、万方数据数字化期刊群、中国学术期刊过刊全文数据库、中国学术期刊（光盘版）、中国学术期刊文摘、中文期刊全文数据库、俄罗斯Рж期刊源等。
正式出版
收录年代

    Electron donor-acceptor complex enabled arylation of dithiocarbamate anions with thianthrenium salts under aqueous micellar conditions

    Rong-Nan YiWei-Min He
    1-2页
      原文链接:
    • 万方数据
    • 维普

    Tuning amino/hydroxyl ratios of nanovesicles to manipulate protein corona-mediated in vivo fate

    Wenhao WangSiyuan PengZhengwei HuangXin Pan...
    3-5页
      原文链接:
    • 万方数据
    • 维普

    Insight into microbial synthesis of metal nanomaterials and their environmental applications:Exploration for enhanced controllable synthesis

    Yuqing LiuYu YangYuhan EChanglong Pang...
    6-15页
    查看更多>>摘要：Microbial fabrication of metal nanoparticles(MNPs)has received significant attention due to the advan-tages of low toxicity,energy efficiency and ecological safety.Diverse groups of MNPs can be synthesized intracellularly or extracellularly by various wild-type microorganisms,including bacteria,fungi,algae and viruses.Synthetic biology approaches,represented by genetic engineering,have been applied to overcome the shortcomings in productivity,stability,and controllability of biosynthetic MNPs.Scanning electron mi-croscope(SEM),transmission electron microscope(TEM)and other characterization techniques assist in deciphering their unique properties.In addition,biosynthetic MNPs have been widely explored for the utilization in environmental remediation and contaminant detection.And machine learning contains a great potential for designing targeted MNPs and predicting their toxicity.This review provides a compre-hensive overview of the research progress in the microbial synthesis of MNPs.An outlook on the current challenges and future prospects in the biologically controllable synthesis and engineering environmental applications of MNPs is also provided in this review.
      原文链接:
    • 万方数据
    • 维普

    Recent advances in near infrared(NIR)electrochemiluminescence luminophores

    Yuyang ZhouZiwang MaoJing-Juan Xu
    16-24页
    查看更多>>摘要：Electrochemiluminescence has been developed as a robust analytical technique owing to its intrinsic ad-vantages,such as near-zero background signal noise,wide dynamic ranges,high sensitivity and low cost and simple equipment.ECL luminophore as the critical component to generate light signals plays signif-icant roles in this robust analytical system.Compared with traditional ECL luminophores,near infrared(NIR)ECL luminophores have attracted significant attentions recently due to their negligible autofluores-cence,lower background interference and deep tissue penetration.Although substantial progresses have been achieved in exploring novel NIR ECL luminophores and elucidating their roles in addressing diverse challenges,there is still scarce of comprehensive reviews on the development of NIR ECL luminophores so far.In this review,the recent advancements on NIR ECL materials,including inorganic metal com-plexes,organic small molecules,metal nanoclusters,quantum dots and lanthanide-based materials,have been thoroughly summarized and discussed.In addition,we also provide a comprehensive overview of the challenges and prospects that lie ahead for the future development of NIR ECL luminophores in the future.
      原文链接:
    • 万方数据
    • 维普

    DNA-based nanosystems to generate reactive oxygen species for nanomedicine

    Zhongyu WangLijun WangHuaixin Zhao
    25-34页
    查看更多>>摘要：Reactive oxygen species(ROS)are essential in various pathological and physiological processes.Develop-ing nanosystems that generate ROS in a controlled manner is of great interest for nanomedicine.DNA nanotechnology offers a promising approach to constructing programmable ROS-generating platforms.By incorporating photosensitizers or metal ions,DNA nanostructures can be designed to produce ROS in a spatially and temporally desired fashion.DNA-based ROS-generating nanosystems hold great potential in intracellular homeostasis regulation,drug release,and cancer therapy.This review summarizes recent advances in developing DNA-based ROS-generating nanosystems,highlights their emerging biomedical applications,and discusses the opportunities and challenges for further applications.DNA nanotechnol-ogy provides a versatile toolkit to construct biocompatible ROS-generating platforms for next-generation nanomedicines.
      原文链接:
    • 万方数据
    • 维普

    Research advances of tetrahedral framework nucleic acid-based systems in biomedicine

    Lihang WangMary Li JavierChunshan LuoTingsheng Lu...
    35-43页
    查看更多>>摘要：This article reviews the latest research advances of tetrahedral framework nucleic acid(tFNA)-based sys-tems in their fabrication,modification,and the potential applications in biomedicine.TFNA arises from the synthesis of four single-stranded DNA chains.Each chain contains brief sequences that complement those found in the other three,culminating in the creation of a pyramid-shaped nanostructure of ap-proximately 10 nanometers in size.The first generation of tFNA demonstrates inherent compatibility with biological systems and the ability to permeate cell membrane effectively.These attributes translate into remarkable capabilities for regulating various cellular biological processes,fostering tissue regeneration,and modulating immune responses.The subsequent evolution of tFNA introduces enhanced adaptability and a relatively higher degree of biological stability.This advancement encompasses structural modifica-tions,such as the addition of functional domains at the vertices or side arms,integration of low molec-ular weight pharmaceuticals,and the implementation of diverse strategies aimed at reversing multi-drug resistance in tumor cells or microorganisms.These augmentations empower tFNA-based systems to be utilized in different scenarios,thus broadening their potential applications in various biomedical fields.
      原文链接:
    • 万方数据
    • 维普

    Tumor microenvironment-sensitive polymeric nanoparticles for synergetic chemo-photo therapy

    Tingting HuChao ShenXueyan WangFengbo Wu...
    44-56页
    查看更多>>摘要：Nanoparticles that employ stimuli-responsive polymeric delivery carriers have emerged as intelligent nanoplatforms with great potential in cancer theranostics,mainly including cancer diagnosis,con-trolled/triggered drug delivery,and real-time monitoring of therapeutic response.Particularly,tumor mi-croenvironment(TME)-responsive polymeric nanocarriers in response to weak acidity,hypoxia,reactive oxygen species(ROS),glutathione(GSH),or tumor enzymes in the TME show great promise in facilitating tumor accumulation,enhancing tumor penetration,prolonging tumor retention,and achieving controlled drug release,thereby improving the efficiency of tumor therapy.Besides,the combination of chemother-apy and phototherapy presents a promising endeavor for the treatment of tumors,which allows for the integration of the advantages of each treatment modality,addressing the shortcomings of the two meth-ods,and amplifying the efficacy of tumor treatment while reducing adverse reactions.This review fo-cuses on the latest progress in the development of TME-responsive polymeric nanoparticles for syner-getic chemo-photo therapy,and discusses the critical challenges and future considerations involved in the fabrication of TME-responsive nanocarriers.
      原文链接:
    • 万方数据
    • 维普

    Advanced metal-organic frameworks-polymer platforms for accelerated dermal wound healing

    Fereshte Hassanzadeh-AfruziMina AziziIman ZareEhsan Nazarzadeh Zare...
    57-65页
    查看更多>>摘要：Skin wound healing is an important aspect of regenerative medicine.Metal-organic frameworks(MOFs)have attracted considerable attention as promising nanomaterials for skin wound healing due to their re-markable versatility,tunable pore size,surface area,targeted delivery of various therapeutic agents,and controlled release properties.The combination of these materials with biocompatible and synthetic poly-mers can help improve their performance in wound regeneration.This review examines the potential of MOF-polymer composites in skin wound healing.Physical and biological chemical properties and meth-ods of making MOFs and their composites have been investigated.In the final section of this review,challenges and future prospects for the development of MOF-polymer composites are stated.
      原文链接:
    • 万方数据
    • 维普

    Advances in synthetic biology-based drug delivery systems for disease treatment

    Yujie LiYa-Nan WangYin-Gen LuoHongcai Yang...
    66-73页
    查看更多>>摘要：With the increasing demand for personalized and precise treatment,the rapid advancement of synthetic biology technology has inevitably led to the development of nanobiology-based drug delivery systems.Synthetic biology-based drug delivery systems are being increasingly used in the treatment of various diseases.On one hand,synthetic biology technology enables the clever combination of chassis cells,bac-teria,and their derivatives with nanomaterials,forming nano-artificial hybrid systems.These systems ef-fectively integrate the functions of both materials,leading to further breakthroughs and optimization of biological functions.On the other hand,synthetic biology strategies guide the self-assembly of modular nanocomponents with biocatalytic or intelligent response functions,resulting in the mimicry of living cell features such as compartmentalization of enzymatic reactions and responsiveness to external stimuli.This provides novel design ideas for the construction of artificial cells.This paper aims to explore the construc-tion and application of biogenic drug delivery systems based on whole cells,cell membrane-encapsulated nanoparticles,exosomes,bacteria,bacterial outer membrane vesicles and artificial cells,taking into ac-count recent advances in this field.The advantages and limitations of current synthetic biology-based nanodrug delivery systems for clinical translation are discussed,and the future prospects of nanotechnol-ogy for intelligent drug diagnostic and therapeutic systems are envisioned.
      原文链接:
    • 万方数据
    • 维普

    A natural nano-platform:Advances in drug delivery system with recombinant high-density lipoprotein

    Zhilong XieGuohui ZhangYa MengYefei Tong...
    74-86页
    查看更多>>摘要：Developing natural nano-platforms with high biocompatibility and natural targeting ability represents great significance for drug delivery.High-density lipoprotein(HDL),a natural lipid-protein complex,plays important roles in physiological activities,particularly in reverse cholesterol transport(RCT)and be closely associated with atherosclerotic cardiovascular diseases.Recent studies have demonstrated that HDLs have the potential to serve as ideal drug carriers.Recombinant HDLs(rHDLs)have been used to en-capsulate substances such as small interfering RNA(siRNA),drugs,and contrast agents,fully utilizing the biocompatibility and targeting ability of rHDL in the body and providing new strategies for drug delivery and disease treatment.In this review,we discussed in detail the basic principles of HDL as a drug delivery system,the mechanisms of targeted drug delivery,and several methods for preparing HDL nanoparticles.Afterward,we comprehensively reviewed the applications of HDL as a drug carrier in cardiovascular dis-eases,cancer treatment(such as glioblastoma,breast cancer,hepatocellular carcinoma and urologic can-cers)and some other fields.Finally,we reviewed the therapeutic effects and safety of HDL nanoparticles in clinical studies.Through a review and summary of these research advances,we aim to fully understand the potential of HDL as a drug carrier in clinical applications,providing valuable references and guidance for future research and expedites the translational application of HDL as drug carriers.
      原文链接:
    • 万方数据
    • 维普