中国化学快报(英文版)2024，Vol.35Issue(1) ：52-63.DOI:10.1016/j.cclet.2023.108511

Quinoline-based anti-MRSA agents:Current development,structure-activity relationships,and mechanisms

Hong Yao Liping Cui Hang Liu Xueyu Li Lin Shen Ruige Yang Shangshang Qin Yong Guo
中国化学快报(英文版)2024，Vol.35Issue(1) ：52-63.DOI:10.1016/j.cclet.2023.108511
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Quinoline-based anti-MRSA agents:Current development,structure-activity relationships,and mechanisms

Hong Yao 1Liping Cui 2Hang Liu 2Xueyu Li 2Lin Shen 2Ruige Yang 2Shangshang Qin 2Yong Guo3
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作者信息

  • 1. College of Veterinary Medicine,Henan Agricultural University,Zhengzhou 450046,China
  • 2. School of Pharmaceutical Sciences,Zhengzhou University,Zhengzhou 450001,China
  • 3. School of Pharmaceutical Sciences,Zhengzhou University,Zhengzhou 450001,China;Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study,School of Pharmaceutical Science,Hengyang Medical School,University of South China,Hengyang 421001,China
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Abstract

Methicillin-resistant Staphylococcus aureus(MRSA),the most common pathogen in hospital and commu-nity environments,can cause serious and even fatal infections.The antibiotics currently used for clinical treatment of MRSA have developed resistance,and there is an urgent need to develop new antimicrobials to treat infections caused by MRSA strains.Quinoline analogues play an important role in the develop-ment of antimicrobials.Herein,we discussed the current development of antibacterial activities of quino-line analogues,mainly for anti-MRSA activity,and their structure-activity relationships(SARs)from the perspective of using the quinoline nucleus to search for novel potential anti-MRSA candidates.Addition-ally,the mechanisms of some representative quinoline analogues against MRSA were clarified.Altogether,this review could provide further insights for the rational development of quinoline-based antibacterial drugs,especially against MRSA.

Key words

Quinoline analogue/Methicillin-resistant Staphylococcus aureus/Antibacterial activity/Structure-activity relationship/Antibacterial mechanism

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基金项目

国家自然科学基金(32272575)

National College Student Innovation and Entrepreneurship Training Program(202210459164)

出版年

2024
中国化学快报(英文版)
中国化学会

中国化学快报(英文版)

CSTPCD
影响因子：0.771
ISSN：1001-8417
参考文献量98
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