Methicillin-resistant Staphylococcus aureus(MRSA),the most common pathogen in hospital and commu-nity environments,can cause serious and even fatal infections.The antibiotics currently used for clinical treatment of MRSA have developed resistance,and there is an urgent need to develop new antimicrobials to treat infections caused by MRSA strains.Quinoline analogues play an important role in the develop-ment of antimicrobials.Herein,we discussed the current development of antibacterial activities of quino-line analogues,mainly for anti-MRSA activity,and their structure-activity relationships(SARs)from the perspective of using the quinoline nucleus to search for novel potential anti-MRSA candidates.Addition-ally,the mechanisms of some representative quinoline analogues against MRSA were clarified.Altogether,this review could provide further insights for the rational development of quinoline-based antibacterial drugs,especially against MRSA.
Hong Yao、Liping Cui、Hang Liu、Xueyu Li、Lin Shen、Ruige Yang、Shangshang Qin、Yong Guo
展开 >
College of Veterinary Medicine,Henan Agricultural University,Zhengzhou 450046,China
School of Pharmaceutical Sciences,Zhengzhou University,Zhengzhou 450001,China
Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study,School of Pharmaceutical Science,Hengyang Medical School,University of South China,Hengyang 421001,China
国家自然科学基金National College Student Innovation and Entrepreneurship Training Program
NETL
NSTL
万方数据
