首页|A H4SiW12O40-catalyzed three-component tandem reaction for the synthesis of 3,3-disubstituted isoindolinones
A H4SiW12O40-catalyzed three-component tandem reaction for the synthesis of 3,3-disubstituted isoindolinones
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A H4SiW12O40-catalyzed three-component tandem reaction of 2-acylbenzoic acids,primary amines and phosphine oxides to form 3,3-disubstituted isoindolinones was developed.By employing H4SiW12O40 as the catalyst and dimethyl carbonate(DMC)as the solvent,a diverse range of 2-acylbenzoic acid deriva-tives and primary amines worked well to give the C3-phosphinoyl-functionalized 3,3-disubstituted isoin-dolinones with the yield range of 61％-87％.Advantages of this transformation include green catalyst and solvent,available starting materials,broad substrate scope,high efficiency and operational simplicity with water as the sole by-product.The strategy achieved an efficient and green molecular fragment assembly to access isoindolinones,which would provide opportunities for the synthesis of potential biologically active molecules in a green manner.
PolyoxometalatesDehydrative couplingThree-component tandem reaction3,3-Disubstituted isoindolinonesOrganic carbonate
Yufeng Liu、Guodong Zeng、Yutao Cheng、Lei Chen、Yunhai Liu、Yongge Wei、Guoping Yang
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School of Chemistry,Biology and Material Science,Jiangxi Province Key Laboratory of Synthetic Chemistry,Jiangxi Key Laboratory for Mass Spectrometry and Instrumentation,East China University of Technology,Nanchang 330013,China
Key Lab of Organic Optoelectronics & Molecular Engineering of Ministry of Education,Department of Chemistry,Tsinghua University,Beijing 100084,China
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