A H4SiW12O40-catalyzed three-component tandem reaction for the synthesis of 3,3-disubstituted isoindolinones

Yufeng Liu ¹Guodong Zeng ¹Yutao Cheng ¹Lei Chen ¹Yunhai Liu ¹Yongge Wei ²Guoping Yang³

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作者信息

1. School of Chemistry,Biology and Material Science,Jiangxi Province Key Laboratory of Synthetic Chemistry,Jiangxi Key Laboratory for Mass Spectrometry and Instrumentation,East China University of Technology,Nanchang 330013,China
2. Key Lab of Organic Optoelectronics & Molecular Engineering of Ministry of Education,Department of Chemistry,Tsinghua University,Beijing 100084,China
3. School of Chemistry,Biology and Material Science,Jiangxi Province Key Laboratory of Synthetic Chemistry,Jiangxi Key Laboratory for Mass Spectrometry and Instrumentation,East China University of Technology,Nanchang 330013,China;Key Lab of Organic Optoelectronics & Molecular Engineering of Ministry of Education,Department of Chemistry,Tsinghua University,Beijing 100084,China
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Abstract

A H4SiW12O40-catalyzed three-component tandem reaction of 2-acylbenzoic acids,primary amines and phosphine oxides to form 3,3-disubstituted isoindolinones was developed.By employing H4SiW12O40 as the catalyst and dimethyl carbonate(DMC)as the solvent,a diverse range of 2-acylbenzoic acid deriva-tives and primary amines worked well to give the C3-phosphinoyl-functionalized 3,3-disubstituted isoin-dolinones with the yield range of 61％-87％.Advantages of this transformation include green catalyst and solvent,available starting materials,broad substrate scope,high efficiency and operational simplicity with water as the sole by-product.The strategy achieved an efficient and green molecular fragment assembly to access isoindolinones,which would provide opportunities for the synthesis of potential biologically active molecules in a green manner.

Key words

Polyoxometalates/Dehydrative coupling/Three-component tandem reaction/3,3-Disubstituted isoindolinones/Organic carbonate

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基金项目

国家自然科学基金(22001034)

江西省自然科学基金(20212BAB213001)

出版年

2024

中国化学快报(英文版)

中国化学会

中国化学快报(英文版)

CSTPCDCSCD

影响因子：0.771

ISSN：1001-8417

参考文献量3

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