首页|Vesicle fusion induced by zwitterionic amphiphilic channels

Vesicle fusion induced by zwitterionic amphiphilic channels

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A new strategy to induce vesicle fusion has been developed by employing pillar[5]arene derivatives that were channel-like and were prepared by appending side chains onto pillar[5]arenes backbones.The chan-nels feature with hydrophilic negatively and positively charged groups at both ends and hydrophobic Trp residues at the outer surface,which endows the channels with amphiphilicity.The zwitterionic am-phiphilic channels could spontaneously incorporate into the bilayer membranes of lipid vesicles to induce vesicle fusion driven by the electrostatic interactions between negatively charged and positively charged groups.

Vesicle fusionPillar[5]areneElectrostatic interactionLipid bilayers

Qingyu Huan、Tao Lin、Yong-Hong Fu、Jun-Li Hou

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Department of Chemistry,Fudan University,Shanghai 200433,China

国家自然科学基金国家自然科学基金上海市科委项目上海市科委项目

2192100321971046STCSM22JC1403700

2024

中国化学快报(英文版)
中国化学会

中国化学快报(英文版)

CSTPCD
影响因子:0.771
ISSN:1001-8417
年,卷(期):2024.35(1)
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