Abstract
A new strategy to induce vesicle fusion has been developed by employing pillar[5]arene derivatives that were channel-like and were prepared by appending side chains onto pillar[5]arenes backbones.The chan-nels feature with hydrophilic negatively and positively charged groups at both ends and hydrophobic Trp residues at the outer surface,which endows the channels with amphiphilicity.The zwitterionic am-phiphilic channels could spontaneously incorporate into the bilayer membranes of lipid vesicles to induce vesicle fusion driven by the electrostatic interactions between negatively charged and positively charged groups.
NETL
NSTL
维普
万方数据