首页|Vesicle fusion induced by zwitterionic amphiphilic channels
Vesicle fusion induced by zwitterionic amphiphilic channels
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A new strategy to induce vesicle fusion has been developed by employing pillar[5]arene derivatives that were channel-like and were prepared by appending side chains onto pillar[5]arenes backbones.The chan-nels feature with hydrophilic negatively and positively charged groups at both ends and hydrophobic Trp residues at the outer surface,which endows the channels with amphiphilicity.The zwitterionic am-phiphilic channels could spontaneously incorporate into the bilayer membranes of lipid vesicles to induce vesicle fusion driven by the electrostatic interactions between negatively charged and positively charged groups.