首页|Recognition and chirality sensing of guanosine-containing nucleotides by an achiral tetraphenylethene-based octacationic cage in water

Recognition and chirality sensing of guanosine-containing nucleotides by an achiral tetraphenylethene-based octacationic cage in water

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The development of molecular probes or systems with the ability of multiple orthogonal responses is an effective approach to precisely detect biomolecules with similar chemical structures.Herein,we report the synthesis of a water-soluble TPE-based octacationic cage(1)with the compressed TPE-containing bilayer,which endows it with good fluorescence properties and potential conformation chirality.As a re-sult,1 exhibits molecular recognition for anionic nucleotides within its two"claw"-like cavities to form 1:2 host-guest complexes in water,companying with selective turn-off fluorescence and turn-on CD re-sponses to G/GTP over other nucleotides.

Host-guest recognitionChirality sensingTetraphenyletheneAchiral cageNucleotide

Honghong Duan、Ting Yang、Qingfang Li、Fan Cao、Pingxia Wang、Liping Cao

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College of Chemistry and Materials Science,Northwest University,Xi'an 710069,China

国家自然科学基金国家自然科学基金Natural Science Basic Research Plan for Distinguished Young Scholars in Shaanxi Province of China霍英东教育基金

22122108219712082021JC-37171010

2024

10.1016/j.cclet.2023.108878

中国化学快报(英文版)
中国化学会

中国化学快报(英文版)

CSTPCD
影响因子：0.771
ISSN：1001-8417
年,卷(期)：2024.35(1)
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