首页|J-aggregation of photosensitizers leads to an ultrahigh drug-loading system for targeted delivery

J-aggregation of photosensitizers leads to an ultrahigh drug-loading system for targeted delivery

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Drug loading capacity is very important in the construction of targeted drug delivery systems(TDDSs)for the improvement of drug delivery efficiency.However,the drug-loading capacity of most nanoma-terials is non-idealistic,and developing the high drug-loading TDDSs is still a critical challenge.In this work,an ultrahigh loading system(denoted as HMPB2)was prepared via J-aggregation of an aza-boron dipyrromethene derivative(Bod)by using hollow MnO2 modified with glucosamine pillar[5]arene as a carrier,which was demonstrated to have typical J-aggregate absorption of Bod,specific cancer cells tar-geting ability,negligible dark cytotoxicity,and potent phototoxicity.This work provides a successful ex-ample to construct an ultrahigh drug-loading system via J-aggregation for targeted delivery.

J-aggregateUltrahigh drug-loadingAza-BODIPYHollow MnO2PhototherapyPillar[n]arene

Yun Qu、Wenjuan Jin、Yichen Wan、Zhichao Pei、Yuxin Pei

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College of Chemistry & Pharmacy,Northwest A&F University,Yangling 712100,China

国家自然科学基金国家自然科学基金Project of Science and Technology of Social Development in Shaanxi ProvinceLife Science Research Core Services(LSRCS)Northwest A&F University

22171230218770882021SF-120

2024

10.1016/j.cclet.2023.108493

中国化学快报(英文版)
中国化学会

中国化学快报(英文版)

CSTPCD
影响因子：0.771
ISSN：1001-8417
年,卷(期)：2024.35(1)
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