Abstract
Drug loading capacity is very important in the construction of targeted drug delivery systems(TDDSs)for the improvement of drug delivery efficiency.However,the drug-loading capacity of most nanoma-terials is non-idealistic,and developing the high drug-loading TDDSs is still a critical challenge.In this work,an ultrahigh loading system(denoted as HMPB2)was prepared via J-aggregation of an aza-boron dipyrromethene derivative(Bod)by using hollow MnO2 modified with glucosamine pillar[5]arene as a carrier,which was demonstrated to have typical J-aggregate absorption of Bod,specific cancer cells tar-geting ability,negligible dark cytotoxicity,and potent phototoxicity.This work provides a successful ex-ample to construct an ultrahigh drug-loading system via J-aggregation for targeted delivery.
基金项目
国家自然科学基金(22171230)
国家自然科学基金(21877088)
Project of Science and Technology of Social Development in Shaanxi Province(2021SF-120)
Life Science Research Core Services(LSRCS)()
Northwest A&F University()
NETL
NSTL
维普
万方数据