Abstract
Early diagnosis and treatment of cancer requires the development of tools that are both sensitive and selective in detecting spermine.In this study,we presented a"supramolecular cyclization-induced emis-sion enhancement"strategy for the sensitive and selective detection of spermine.A new pillar[5]arene probe(P1)demonstrated excellent solution/solid dual-state emission properties,and the addition of cer-tain spermine(Spm)resulted in fluorescence enhancement due to the synergy of multiple weak inter-actions that restricted the free motion of P1 in the P1⊃Spm complex.This mechanism was further con-firmed by time-resolved spectroscopy,DFT calculations,and IGM analysis.With its low limit of detection and high selectivity,P1 is a promising tool for measuring spermine in artificial urine samples.
基金项目
国家自然科学基金(22071066)
国家自然科学基金(22071065)
国家重点研发计划(2016YFA0602900)
广东省自然科学基金(2018B030311008)
Guangzhou Science and Technology Project,China(202102020802)
NETL
NSTL
维普
万方数据