中国化学快报(英文版)2024，Vol.35Issue(1) ：300-304.DOI:10.1016/j.cclet.2023.108193

Talaroclauxins A and B:Duclauxin-ergosterol and duclauxin-polyketide hybrid metabolites with complicated skeletons from Talaromyces stipitatus

Qin Li Mi Zhang Xiaotian Zhang Lanqin Li Meijia Zheng Jinbing Kang Fei Liu Qun Zhou Xiaonian Li Weiguang Sun Junjun Liu Chunmei Chen Hucheng Zhu Yonghui Zhang
中国化学快报(英文版)2024，Vol.35Issue(1) ：300-304.DOI:10.1016/j.cclet.2023.108193
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  • 维普
  • 万方数据

Talaroclauxins A and B:Duclauxin-ergosterol and duclauxin-polyketide hybrid metabolites with complicated skeletons from Talaromyces stipitatus

Qin Li 1Mi Zhang 2Xiaotian Zhang 1Lanqin Li 1Meijia Zheng 1Jinbing Kang 1Fei Liu 1Qun Zhou 1Xiaonian Li 3Weiguang Sun 1Junjun Liu 1Chunmei Chen 1Hucheng Zhu 1Yonghui Zhang1
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作者信息

  • 1. Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation,School of Pharmacy,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China
  • 2. Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation,School of Pharmacy,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China;Department of In Vitro Diagnostic Reagent,National Institutes for Food and Drug Control,Beijing 100050,China
  • 3. State Key Laboratory of Phytochemistry and Plant Resources in West China,Kunming Institute of Botany,Chinese Academy of Sciences,Kunming 650201,China
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Abstract

Talaroclauxins A and B(1 and 2),two novel duclauxin hybrids,were obtained from Talaromyces stipitatus,along with three new(3-5)and one known analogue(6).Their structures were determined by NMR spectroscopy,HRESIMS,single-crystal X-ray diffraction,and quantum chemical calculations.Compound 1 is the first example of duclauxin-ergosterol hybrid featuring an unprecedented dodecacyclic ring system formed via a[4+2]cycloaddition,while compound 2,bearing an unusual 6/6/6/5/6/6/6/6 ring system,is a new member of the rare duclauxin-polyketide hybrid class of natural products.Plausible biosynthetic pathways for 1-6 are proposed.Compound 5 displayed moderate neuroprotective effects in glutamate sodium-induced SH-SY5Y cells.

Key words

Talaromyces stipitatus(Trichocomaceae)/Duclauxin hybrids/Single-crystal X-ray diffraction/Biosynthetic pathways/Neuroprotective effects

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基金项目

Program for Changjiang Scholars of Ministry of Education of the People's Republic of China(T2016088)

国家杰出青年科学基金(81725021)

National Natural Science Foundation for Excellent Young Scholars(81922065)

国家自然科学基金(81721005)

国家自然科学基金(82173706)

Science and Technology Major Project of Hubei Province(2021ACA012)

Research and Development Program of Hubei Province(2020BCA058)

Academic Frontier Youth Team of HUST(2017QYTD19)

Integrated Innovative Team for Major Human Diseases Program of Tongji Medical College(HUST)()

出版年

2024
中国化学快报(英文版)
中国化学会

中国化学快报(英文版)

CSTPCDCSCD
影响因子：0.771
ISSN：1001-8417
参考文献量22
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