首页|Talaroclauxins A and B:Duclauxin-ergosterol and duclauxin-polyketide hybrid metabolites with complicated skeletons from Talaromyces stipitatus

Talaroclauxins A and B:Duclauxin-ergosterol and duclauxin-polyketide hybrid metabolites with complicated skeletons from Talaromyces stipitatus

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Talaroclauxins A and B(1 and 2),two novel duclauxin hybrids,were obtained from Talaromyces stipitatus,along with three new(3-5)and one known analogue(6).Their structures were determined by NMR spectroscopy,HRESIMS,single-crystal X-ray diffraction,and quantum chemical calculations.Compound 1 is the first example of duclauxin-ergosterol hybrid featuring an unprecedented dodecacyclic ring system formed via a[4+2]cycloaddition,while compound 2,bearing an unusual 6/6/6/5/6/6/6/6 ring system,is a new member of the rare duclauxin-polyketide hybrid class of natural products.Plausible biosynthetic pathways for 1-6 are proposed.Compound 5 displayed moderate neuroprotective effects in glutamate sodium-induced SH-SY5Y cells.

Talaromyces stipitatus(Trichocomaceae)Duclauxin hybridsSingle-crystal X-ray diffractionBiosynthetic pathwaysNeuroprotective effects

Qin Li、Mi Zhang、Xiaotian Zhang、Lanqin Li、Meijia Zheng、Jinbing Kang、Fei Liu、Qun Zhou、Xiaonian Li、Weiguang Sun、Junjun Liu、Chunmei Chen、Hucheng Zhu、Yonghui Zhang

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Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation,School of Pharmacy,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China

Department of In Vitro Diagnostic Reagent,National Institutes for Food and Drug Control,Beijing 100050,China

State Key Laboratory of Phytochemistry and Plant Resources in West China,Kunming Institute of Botany,Chinese Academy of Sciences,Kunming 650201,China

Program for Changjiang Scholars of Ministry of Education of the People's Republic of China国家杰出青年科学基金National Natural Science Foundation for Excellent Young Scholars国家自然科学基金国家自然科学基金Science and Technology Major Project of Hubei ProvinceResearch and Development Program of Hubei ProvinceAcademic Frontier Youth Team of HUSTIntegrated Innovative Team for Major Human Diseases Program of Tongji Medical College(HUST)

T2016088817250218192206581721005821737062021ACA0122020BCA0582017QYTD19

2024

10.1016/j.cclet.2023.108193

中国化学快报(英文版)
中国化学会

中国化学快报(英文版)

CSTPCD
影响因子：0.771
ISSN：1001-8417
年,卷(期)：2024.35(1)
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