IR780/Gemcitabine-conjugated metal-phenolic network enhanced photodynamic cancer therapy

Songtao Zhou ¹Hao Tian ²Jie Yan ²Zhan Zhang ²Guohao Wang ²Xinying Yu ²Wei Sang ²Bei Li ²Greta S.P.Mok ³Jie Song ⁴Yunlu Dai²

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作者信息

1. Cancer Center and Institute of Translational Medicine,Faculty of Health Sciences,University of Macau,Macau 999078,China;MoE Frontiers Science Center for Precision Oncology,University of Macau,Macau 999078,China;Institute of Basic Medicine and Cancer(IBMC),Chinese Academy of Sciences,The Cancer Hospital of the University of Chinese Academy of Sciences,Hangzhou 310022,China
2. Cancer Center and Institute of Translational Medicine,Faculty of Health Sciences,University of Macau,Macau 999078,China;MoE Frontiers Science Center for Precision Oncology,University of Macau,Macau 999078,China
3. Biomedical Imaging Laboratory(BIG),Department of Electrical and Computer Engineering,Faculty of Science and Technology,University of Macau,Macau 999078,China
4. Institute of Basic Medicine and Cancer(IBMC),Chinese Academy of Sciences,The Cancer Hospital of the University of Chinese Academy of Sciences,Hangzhou 310022,China
折叠

Abstract

Photodynamic therapy(PDT)is a clinically approved cancer treatment that uses energy of light to gen-erate active substances that cause damage to the cancer.Photosensitizers are employed to absorb light and generate toxic reactive oxygen species(ROS)to damage biomolecules like DNA.At the same time,some chemotherapy drugs like nucleotide analogues can provide mechanism-guided promotion in the treatment efficacy of PDT.However,the photosensitizer and chemotherapy drugs used in PDT is usu-ally organic molecules,which suffers from bad solubility,fast clearance,and acute toxicity.To achieve targeted treatment,a reasonable delivery system is necessary.Therefore,we reported a metal-phenolic network where IR780 and gemcitabine were coupled chemically to overcome these shortcomings.The enhanced PDT effects can be realized by the promoted cell death both in vitro and in vivo.Moreover,the synergistic therapy also induced T-cell mediated anti-tumor immune response,which was significant for the inhibition of distant tumor growth.This work expanded the biomedical application of metal-phenolic materials and contribute to the wider application of photodynamic cancer therapy.

Key words

Metal phenolic network/IR780/Photodynamic therapy/Breast cancer/Gemcitabine

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基金项目

国家自然科学基金(32171318)

国家自然科学基金(32222090)

国家自然科学基金(32101069)

Faculty of Health Sciences,University of Macau,the Multi-Year Research Grant(MYRG)of University of Macau(MYRG2022-00011-FHS)

Science and Technology Development Fund,Macau SAR(0103/2021/A)

Science and Technology Development Fund,Macau SAR(0002/2021/AKP)

Shenzhen Science and Technology Innovation Commission,Shenzhen-Hong Kong-Macau Science and Technology Plan C(SGDX20201103093600004)

Dr.Stanley Ho Medical Development Foundation(SHMDF-OIRFS/2022/002)

Proteomics,Metabolomics,and Drug Development Core,Animal Research Core,and Biological Imaging and Stem Cell Core in the Facu()

出版年

2024

中国化学快报(英文版)

中国化学会

中国化学快报(英文版)

CSTPCD

影响因子：0.771

ISSN：1001-8417

参考文献量2

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