Abstract
The recent advances in accelerated polymerization of N-carboxyanhydrides(NCAs)offer an effective strat-egy to simplify the preparation of polypeptide materials.However,the fine-tuning of polymerization ki-netics,which is critical to differentiate the main polymerization and the side reactions,remains largely unexplored.Herein we report the modulation of polymerization rate of NCA in a water/oil biphasic sys-tem.By altering the aqueous pH,the initial location of the initiators,and the pKa of initiating amines,we observed the change in polymerization time from several minutes to a few hours.Due to the high in-terfacial activity and low pKa value,controlled polymerization was observed from multi-amine initiators even if they were initially located in the aqueous phase.This work not only improves our understand-ing on the biphasic polymerization mechanism,but also facilitates preparation of versatile polypeptide materials.
基金项目
国家自然科学基金(22101194)
国家自然科学基金(52233015)
江苏省自然科学基金(BK20210733)
Suzhou Municipal Science and Technology Bureau(ZXL2021447)
苏州纳米科技协同创新中心项目()
高等学校学科创新引智计划(111计划)()
Joint International Research Laboratory of Carbon-Based Functional Materials and Devices()
Suzhou Key Laboratory of Nanotechnology and Biomedicine()
NETL
NSTL
维普
万方数据