首页|Modulation of polymerization rate of N-carboxyanhydrides in a biphasic system
Modulation of polymerization rate of N-carboxyanhydrides in a biphasic system
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The recent advances in accelerated polymerization of N-carboxyanhydrides(NCAs)offer an effective strat-egy to simplify the preparation of polypeptide materials.However,the fine-tuning of polymerization ki-netics,which is critical to differentiate the main polymerization and the side reactions,remains largely unexplored.Herein we report the modulation of polymerization rate of NCA in a water/oil biphasic sys-tem.By altering the aqueous pH,the initial location of the initiators,and the pKa of initiating amines,we observed the change in polymerization time from several minutes to a few hours.Due to the high in-terfacial activity and low pKa value,controlled polymerization was observed from multi-amine initiators even if they were initially located in the aqueous phase.This work not only improves our understand-ing on the biphasic polymerization mechanism,but also facilitates preparation of versatile polypeptide materials.
Guonan Ji、Xuetao Zheng、Xiangdie Hou、Xiao Sun、Shijie Wang、Xiaohong Li、Jianjun Cheng、Ziyuan Song
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Institute of Functional Nano & Soft Materials(FUNSOM),Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices,Soochow University,Suzhou 215123,China
School of Engineering,Westlake University,Hangzhou 310030,China
The Key Lab of Health Chemistry and Molecular Diagnosis of Suzhou,College of Chemistry,Chemical Engineering and Materials Science,Soochow University,Suzhou 215123,China
Research Center for Industries of the Future,Westlake University,Hangzhou 310030,China
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国家自然科学基金国家自然科学基金江苏省自然科学基金Suzhou Municipal Science and Technology Bureau苏州纳米科技协同创新中心项目高等学校学科创新引智计划(111计划)Joint International Research Laboratory of Carbon-Based Functional Materials and DevicesSuzhou Key Laboratory of Nanotechnology and Biomedicine
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