首页|Probing mitochondrial damage using a fluorescent probe with mitochondria-to-nucleolus translocation

Probing mitochondrial damage using a fluorescent probe with mitochondria-to-nucleolus translocation

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Mitochondrial damage is closely related to the occurrence of many diseases.However,accurate moni-toring and reporting of mitochondrial damage are not easy.Here,we developed a small molecule fluo-rescent probe named CB-C1,which has splendid spectral properties(large Stokes shift,strong affinity for RNA,etc.)and excellent targeting ability to intracellular mitochondria.After mitochondria were damaged by external stimuli,CB-C1 would light up the nucleolus as a signal reporter.The cascade imaging of mi-tochondria and nucleolus using CB-C1 can monitor and visualize the mitochondrial status in living cells in real-time.Based on the above advantages,the probe CB-C1 has reference significance for the related research of mitochondrial damage and the prevention and treatment of related diseases.

Fluorescent probeMitochondria targetingNucleolus translocationMitochondrial damage diagnosisFluorescence imaging

Chi Li、Chong Zong、Yang Liu、Zhiqiang Liu、Kang-Nan Wang、Xiaoqiang Yu

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State Key Laboratory of Crystal Materials,Shandong University,Ji'nan 250100,China

Shenzhen Research Institute of Shandong University,Shenzhen 518057,China

Shenzhen Science and Technology Research and Development Funds国家自然科学基金国家自然科学基金国家自然科学基金Guangdong Basic and Applied Basic Research FoundationQilu Young Scholars Program of Shandong University

JCYJ201908061554091045215022221672130520731632019A1515110356

2024

10.1016/j.cclet.2023.108323

中国化学快报(英文版)
中国化学会

中国化学快报(英文版)

CSTPCD
影响因子：0.771
ISSN：1001-8417
年,卷(期)：2024.35(1)
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