Abstract
Mitochondrial damage is closely related to the occurrence of many diseases.However,accurate moni-toring and reporting of mitochondrial damage are not easy.Here,we developed a small molecule fluo-rescent probe named CB-C1,which has splendid spectral properties(large Stokes shift,strong affinity for RNA,etc.)and excellent targeting ability to intracellular mitochondria.After mitochondria were damaged by external stimuli,CB-C1 would light up the nucleolus as a signal reporter.The cascade imaging of mi-tochondria and nucleolus using CB-C1 can monitor and visualize the mitochondrial status in living cells in real-time.Based on the above advantages,the probe CB-C1 has reference significance for the related research of mitochondrial damage and the prevention and treatment of related diseases.
基金项目
Shenzhen Science and Technology Research and Development Funds(JCYJ20190806155409104)
国家自然科学基金(52150222)
国家自然科学基金(21672130)
国家自然科学基金(52073163)
Guangdong Basic and Applied Basic Research Foundation(2019A1515110356)
Qilu Young Scholars Program of Shandong University()
NETL
NSTL
维普
万方数据