Self-adaptive hydrogel for breast cancer therapy via accurate tumor elimination and on-demand adipose tissue regeneration

Ran Tian ¹Xinyu Qiub ²Wenyun Mu ¹Bolei Cai ³Zhongning Liu ⁴Shiyu Liu ⁵Xin Chen¹

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作者信息

1. School of Chemical Engineering and Technology,Department of Chemical Engineering,Shaanxi Key Laboratory of Energy Chemical Process Intensification,Xi'an Jiao Tong University,Xi'an 710049,China
2. School of Stomatology,State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Clinical Research Center for Oral Diseases,Department of Preventive Dentistry,The Fourth Military Medical University,Xi'an 710032,China
3. School of Stomatology,State Key Laboratory of Military Stomatology,Department of Oral and Maxillofacial Surgery,The Fourth Military Medical University,Xi'an 710032,China
4. Department of Prosthodontics,Peking University School and Hospital of Stomatology,National Clinical Research Center for Oral Diseases,National Engineering Laboratory for Digital and Material Technology of Stomatology,Beijing Key Laboratory of Digital Stomatology,Beijing 100081,China
5. School of Stomatology,State Key Laboratory of Military Stomatology,National Clinical Research Center for Oral Diseases,Shaanxi International Joint Research Center for Oral Diseases,Center for Tissue Engineering,The Fourth Military Medical University,Xi'an 710032,China
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Abstract

The irregular defects and residual tumor tissue after surgery are challenges for effective breast cancer treatment.Herein,a smart hydrogel with self-adaptable size and dual responsive cargos release was fab-ricated to treat breast cancer via accurate tumor elimination,on-demand adipose tissue regeneration and effective infection inhibition.The hydrogel consisted of thiol groups ended polyethylene glycol(SH-PEG-SH)and doxorubicin encapsulated mesoporous silica nanocarriers(DOX@MSNs)double crosslinked hyaluronic acid(HA)after loading of antibacterial peptides(AP)and adipose-derived stem cells(ADSCs).A pH-cleavable unsaturated amide bond was pre-introduced between MSNs and HA frame to perform the tumor-specific acidic environment dependent DOX@MSNs release,meanwhile an esterase degradable glyceryl dimethacrylate cap was grafted on MSNs,which contributed to the selective chemotherapy in tumor cells with over-expressed esterase.The bond cleavage between MSNs and HA would also cause the swelling of the hydrogel,which not only provide sufficient space for the growth of ADSCs,but allows the hydrogel to fully fill the irregular defects generated by surgery and residual tumor atrophy,resulting in the on-demand regeneration of adipose tissue.Moreover,the sustained release of AP could be simul-taneously triggered along with the size change of hydrogel,which further avoided bacterial infection to promote tissue regeneration.

Key words

Smart hydrogel with self-adaptable size/Breast cancer therapy/Dual responsive cargoes release/Selective tumor elimination/On-demand adipose tissue regeneration/Effective bacteria inhibition

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基金项目

National High Level Talents Special Support Plan()

the"Young Talent Support Plan"of Xi'an Jiaotong University()

陕西省自然科学基金(2022JZ-48)

国家自然科学基金(82272141)

Shaanxi Provincial Key Research and Development Plan Project(2023-JC-QN-0260)

出版年

2024

中国化学快报(英文版)

中国化学会

中国化学快报(英文版)

CSTPCD

影响因子：0.771

ISSN：1001-8417

参考文献量40

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