首页|H2S-releasing adhesive hydrogel as oral radioprotectant for gastrointestinal tract radioprotection

H2S-releasing adhesive hydrogel as oral radioprotectant for gastrointestinal tract radioprotection

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Radiation damage can cause a series of gastrointestinal(GI)tract diseases.The development of safe and effective GI tract radioprotectants still remains a great challenge clinically.Here,we firstly re-port an oral radioprotectant Gel@GYY that integrates a porous gelatin-based(Gel)hydrogel and a pH-responsive hydrogen sulfide(H2S)donor GYY4137(morpholin-4-ium 4 methoxyphenyl(morpholino)phos-phinodithioate).Gel@GYY has a remarkable adhesion ability and long retention time,which not only en-ables responsive release of low-dose H2S in stomach and subsequently sustained release of H2S in the whole intestinal tract especially in the colon,but also ensures a close contact between H2S and GI tract.The released H2S can effectively scavenge free radicals induced by X-ray radiation,reduce lipid peroxida-tion level,repair DNA damage and recover vital superoxide dismutase and glutathione peroxidase activi-ties.Meanwhile,the released H2S inhibits radiation-induced activation of nuclear factor κB(NF-κB),thus reducing inflammatory cytokines levels in GI tract.After treatment,Gel@GYY displays efficient excretion from mice body due to its biodegradability.This work provides a new insight for therapeutic application of intelligent H2S-releasing oral delivery system and potential alternative to clinical GI physical damage protectant.

RadiationGastrointestinal tract radioprotectionHydrogen sulfide gas therapyGelatin-based hydrogelFree radicals scavenging

Peng Shan、Jing Liao、Jiayi Li、Chengyan Wang、Jie Zhou、Linqiang Mei、Yunlu Dai、Qiang Wang、Wenyan Yin

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Laboratory for Micro-sized Functional Materials,Department of Chemistry and College of Elementary Education,Capital Normal University,Beijing 100048,China

CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety,Institute of High Energy Physics,Chinese Academy of Sciences,Beijing 100049,China

Department of Pharmacy,Southwest Hospital,The Third Military Medical University,Chongqing 400038,China

Cancer Centre and Institute of Translational Medicine,Faculty of Health Sciences,University of Macau,Macau SAR 999078,China

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国家自然科学基金国家自然科学基金Sheng Yuan Cooperation北京市自然科学基金directional institutionalized scientific research platform relies on Beijing Synchrotron Radiation Facility of Chinese Acade

22175182214711032021SYHZ00482202064

2024

10.1016/j.cclet.2023.108545

中国化学快报(英文版)
中国化学会

中国化学快报(英文版)

CSTPCD
影响因子：0.771
ISSN：1001-8417
年,卷(期)：2024.35(1)
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