首页|Photoinduced palladium-catalyzed 1,3-diene-selective fluoroalkylamination compounds as potential bactericidal agent against Xanthomonas oryzae pv.oryzae

Photoinduced palladium-catalyzed 1,3-diene-selective fluoroalkylamination compounds as potential bactericidal agent against Xanthomonas oryzae pv.oryzae

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A series of photoinduced palladium-catalyzed 1,3-diene-selective fluoroalkylamination derivatives was ra-tionally synthesized based on diversity-oriented synthesis via cross coupling of 1,3-dienes,amines and fluoroalkyl iodides.The reaction featured good function group tolerance and a broad substrate scope,which could be extended to the late-stage modification of bioactive molecules.Bactericidal activity of all the compounds against Xanthomonas oryzae pv.oryzae(Xoo)was evaluated.Among them,compound E14 showed significant activity against Xanthomonas oryzae pv.oryzae(Xoo)with half maximal effective con-centration(EC50)value of 6.61μmol/mL.In pot experiments,the results showed that E14 could control rice bacterial blight with protective and curative efficiencies of 37.5％and 63.2％at 200μg/mL,respec-tively.Additionally,a plausible mechanism for antibacterial behavior of E14 was proposed by electron microscopy,flow cytometry,reactive oxygen species detection,and biofilm assay.In current work,it can promote the development of photoinduced palladium-catalyzed 1,3-diene-selective fluoroalkyl amination compounds as prospective antibacterial agent bearing an intriguing mode of action.

1,3-Diene-selective fluoroalkylamination derivativesXanthomonas oryzae pv.oryzaeAntibacterial activityElectron microscopyReactive oxygenFlow cytometry

Yu Shi、Zhao-Sheng Zhang、Jiang Shao、Chen Fu、Lan-Tu Xiong、Zhao-Dong Li、Zi-Ning Cui

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National Key Laboratory of Green Pesticide,Integrative Microbiology Research Centre,Guangdong Province Key Laboratory of Microbial Signals and Disease Control,College of Plant Protection,South China Agricultural University,Guangzhou 510642,China

Henry Fok School of Biology and Agriculture,Shaoguan University,Shaoguan 512005,China

College of Materials and Energy,South China Agricultural University,Guangzhou 510642,China

国家自然科学基金National science Fund for Distinguished Young Scholars of Guangdong ProvinceInternational Science and Technology Cooperation Program in GuangdongInternational Science and Technology Cooperation Program in Guangdong

320724502021B15150201072020A05051000482022A0505050060

2024

10.1016/j.cclet.2023.108794

中国化学快报(英文版)
中国化学会

中国化学快报(英文版)

CSTPCD
影响因子：0.771
ISSN：1001-8417
年,卷(期)：2024.35(1)
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