Abstract
As a new concept having emerged in last few years,the"deep eutectic solvents"(DESs)effect inte-grated into the imprinting technology inevitably exposes design limitations of stimuli-responsive molec-ularly imprinted polymers(MIPs),as well as inadequate analysis of the adsorption performance of MIPs.Herein,a simple yet defined N-isopropylacrylamide/(3-acrylamidopropyl)trimethylammonium chloride(NIPAM/APTMAC)binary DESs system was proposed to prepare intelligent MIPs with thermo-sensitivity.Accordingly,magnetic and thermo-responsive MIPs based on functional monomers-derived DESs(TM-DESs-MIPs1)were synthesized,revealing DESs effect-regulated affinity/kinetics for the enhanced adsorp-tion capability,eco-friendly thermo-regulated elution for high release efficiency,and simple magnetic separation,along with superior selectivity to rhein(RH)and good regeneration ability.TM-DESs-MIPs1 were utilized to extract RH from Cassiae semen samples coupled with high performance liquid chro-matography(HPLC),yielding satisfactory recoveries(79.47％-110.82％)and low limits of detection(LOD)(16.67 μg/L).Another two kinds of MIPs adopting the thermo-responsive moiety-derived DESs effect strat-egy further demonstrated great applicability of such intelligent MIPs for analyses of complicated samples.
基金项目
国家重点研发计划(2019YFC1604904)
国家自然科学基金(32101212)
江西省自然科学基金(20224ACB215009)
Research Program of State Key Laboratory of Food Science and Technology in Nanchang University(SKLF-ZZB-202127)
NETL
NSTL
万方数据