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Synthetic host-guest pairs as novel bioorthogonal tools for pre-targeting

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Due to its simplicity,high efficiency,and chemo-selectivity,bioorthogonal chemistry has shown a great application potential in pre-targeting.Currently,four bioorthogonal pairs as targeting tools,including(strept)avidin/biotin,antibody/antigen,oligonucleotide hybridization and IEDDA tools,have been devel-oped and applied in targeted delivery.Nevertheless,all of these tools still suffer from some limitations,such as difficult modification,biochemical fragility and larger molecular weight for biological associa-tion tools,as well as chemical instability for IEDDA tools.Synthetic host-guest pairs with relatively small molecular sizes not only possess strong chemical stability,but also have the features of fast conjugation rate,tunable binding affinity,easy modification,and high chemo-selectivity.Consequently,they can be used as a novel non-covalent bioorthogonal tool for pre-targeting.In order to further promote the de-velopment of host-guest pairs as novel bioorthogonal tools for pre-targeted delivery,we firstly calculate their conversion rate to make researcher aware of their unique advantages;next,we summarize the re-cent research progress in this area.The future perspectives and limitations of these unique tools will be discussed.This review will provide a systemic overview of the development of synthetic host-guest pairs as novel bioorthogonal tools for pre-targeting,and may serve as a"go for"resort for researchers who are interested in searching for new synthetic tools to improve pre-targeting.

Bioorthogonal chemistrySynthetic host-guest pairsPre-targetingMolecular recognitionBiomedical applications

Yan-Long Ma、Shi Yan、Xiong-Jie Xu、Hua Cao、Ruibing Wang

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School of Chemistry and Chemical Engineering and Guangdong Cosmetics Engineering & Technology Research Center,Guangdong Pharmaceutical University,Zhongshan 528458,China

State Key Laboratory of Quality Research in Chinese Medicine,and the Institute of Chinese Medical Science,University of Macau,Macau 999078,China

广州市科技计划国家自然科学基金国家自然科学基金Innovation Team Project of Universities in Guangdong ProvinceScientific and Technological Innovation Leading Talent Project of Zhongshan CityKey Projects of Social Welfare and Basic Research of Zhongshan City

20210300008922271323220712752020KCXTD009LJ20210092021B2012

2024

10.1016/j.cclet.2023.108645

中国化学快报(英文版)
中国化学会

中国化学快报(英文版)

CSTPCD
影响因子：0.771
ISSN：1001-8417
年,卷(期)：2024.35(2)
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