首页|Strategies and opportunities of micro/nano delivery systems for targeted therapy of ulcerative colitis:Focus on underlying mechanisms and future perspectives

Strategies and opportunities of micro/nano delivery systems for targeted therapy of ulcerative colitis:Focus on underlying mechanisms and future perspectives

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Ulcerative colitis(UC)is a common progressive inflammatory disease whose incidence has increased rapidly in recent years,and can develop into colorectal cancer in severe cases.There are currently no adequate or effective treatments for UC due to the fact that some patients have found suboptimal results after repeated administration,while others have experienced adverse effects.With the rapid development of nanotechnology,developing innovative colon-targeting platforms is essential to improving efficacy,re-ducing side effects,and improving patient compliance.In this review,we summarize the pathophysiolog-ical characteristics of UC and the most recent status of numerous nanodrug delivery systems based on different targeting mechanisms in treating UC.Oral,intravenous,and rectal drug delivery nanoparticles targeting the colon are discussed,which can provide ideas for the design of colon-targeting nanoparticles for the treatment of colon diseases,especially for the treatment of UC.Last but not least,we provide a glimpse into the future of colon-targeted delivery systems,as well as future advancements in the field.

Ulcerative colitisPhysiological characteristicsColon-specific drug deliveryMechanisms of actionTargeted therapy of UC

Zihan Liu、Han Liu、Jialing Cheng、Hongliang Wang、Yanfang Yang、Jun Ye、Yuling Liu

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State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences &Peking Union Medical College,Beijing 100050,China

Beijing Key Laboratory of Drug Delivery Technology and Novel Formulation,Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing 100050,China

北京市科技新星计划北京市科技新星计划北京市自然科学基金中央高校基本科研业务费专项Chinese Academy of Medical Sciences(CAMS)Innovation Fund for Medical SciencesChinese Academy of Medical Sciences(CAMS)Innovation Fund for Medical Sciences

Z21110000212112720220484219L21205933320211012021-I2M-1-0262021-I2M-1-028

2024

10.1016/j.cclet.2023.109074

中国化学快报(英文版)
中国化学会

中国化学快报(英文版)

CSTPCD
影响因子：0.771
ISSN：1001-8417
年,卷(期)：2024.35(2)
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