首页|Heptamethine cyanines in bioorthogonal chemistry
Heptamethine cyanines in bioorthogonal chemistry
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Due to their excellent fluorescence properties and biological function,cyanine dyes have been widely ap-plied in biological imaging.Heptamethine cyanine(Cy7)dyes,as a type of classic near-infrared(NIR)flu-orescent dyes,are considered as one of the effective fluorescent tools in the living organisms due to their good biocompatibility and very low background interference.Bioorthogonal reactions performed in living cells and tissues have developed by leaps and bounds in recent years.The NIR fluorescent labeling tech-nique involving cyanine has attracted widespread attention.This review summarizes their recent applica-tion in the field of bioorthogonal imaging,mainly concluding Cy7-type dyes,labeling strategy,bioimaging application,etc.We expect this work can provide some helps for the studies of NIR bioorthogonal reac-tion in vivo.
National Key Laboratory of Green Pesticide,International Joint Research Center for Intelligent Biosensor Technology and Health,College of Chemistry,Central China Normal University,Wuhan 430079,China
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