中国化学快报(英文版)2024，Vol.35Issue(2) ：151-162.DOI:10.1016/j.cclet.2023.109149

Advanced nano drug delivery systems for neuroprotection against ischemic stroke

Chenchen Xie Jun Liao Ning Zhang Yuhan Sun Yi Li Liyan Xiong Yingnan Zhang Xiaoyan Liu Wei Su Heming Chen Ping Zeng Xiaoqing Zhang Ying Lu Tingfang Wang Chuan Zhang
中国化学快报(英文版)2024，Vol.35Issue(2) ：151-162.DOI:10.1016/j.cclet.2023.109149
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Advanced nano drug delivery systems for neuroprotection against ischemic stroke

Chenchen Xie 1Jun Liao 1Ning Zhang 2Yuhan Sun 3Yi Li 1Liyan Xiong 1Yingnan Zhang 3Xiaoyan Liu 1Wei Su 1Heming Chen 1Ping Zeng 4Xiaoqing Zhang 2Ying Lu 3Tingfang Wang 1Chuan Zhang1
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作者信息

  • 1. Shanghai Engineering Research Center of Organ Repair,School of Medicine,Shanghai University,Shanghai 200444,China
  • 2. Department of pharmacy,the International Peace Maternity and Child Health Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai 200030,China
  • 3. Department of Pharmaceutical Science,School of Pharmacy,Naval Medical University,Shanghai 200433,China
  • 4. School of Pharmacy,Shanghai Jiao Tong University,Shanghai 200040,China
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Abstract

Ischemic stroke(IS)represents a significant threat to brain health due to its elevated mortality and dis-ability rates.The efficacy of small-molecule neuroprotective agents has been impeded by challenges asso-ciated with traversing the blood-brain barrier(BBB)and limited bioavailability.Conversely,advanced nano drug delivery systems hold promise for overcoming these obstacles by facilitating efficient transportation across the BBB and maintaining optimal drug concentrations.This review aims to explore advanced neu-roprotective nano drug delivery systems as a means of effectively administering neuroprotective agents to the brain using pharmaceutical approaches in the treatment of IS.By examining these systems,re-searchers and clinicians can gain valuable insights and innovative concepts,illuminating the potential of advanced neuroprotective nano drug delivery systems.Leveraging these advancements can drive the progress of pioneering and efficacious therapeutic interventions for IS.

Key words

Target/Blood-brain barrier/Ischemic stroke/Nano drug delivery/Neuroprotection

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基金项目

上海市自然科学基金(20ZR1420000)

Shanghai Shen Kang Center Research Physician Training Program on Innovation and Translation Capabilities(SHDC2022CRS051)

Three-Year Action Plan for Improving Clinical Research Capacity of International Peace Maternal and Child Health Hospital,Shangh(IPMCH2022CR1-05)

出版年

2024
中国化学快报(英文版)
中国化学会

中国化学快报(英文版)

CSTPCDCSCD
影响因子：0.771
ISSN：1001-8417
参考文献量118
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