首页|Drug delivery systems for colorectal cancer chemotherapy

Drug delivery systems for colorectal cancer chemotherapy

扫码查看
原文链接
  • 万方数据
  • 维普
Colorectal cancer causes the third most common type of malignant tumors with high morbidity and mor-tality.Chemotherapy is currently one of the most effective and common treatments for colorectal cancer.However,the poor water solubility of some chemotherapeutics,untargeted drug delivery,and the un-desirable systemic side effects of conventional treatment remain the major issues for colorectal cancer chemotherapy.Fortunately,drug delivery systems(DDS)based on biomaterials have been widely investi-gated and found to be capable of resolving those issues with good performance.Therefore,the main goal of this review is to summarize and discuss the progress and potential advantages of different DDS for colorectal cancer chemotherapy.We not only reviewed the nanocarriers used to improve the solubility of chemotherapeutics,including liposomes,micelles,and nanoparticles,but also discussed targeted DDS based on specific ligand-receptor recognition and tumor microenvironmental stimulus responses.Further-more,locally administered systems based on hydrogels and microspheres,which have been shown to increase drug accumulation at the tumor site while decreasing systemic toxicity,were also emphasized.DDS provides a good option for improving the efficacy of chemotherapy in the treatment of colorectal cancer.

Colorectal cancerChemotherapyDrug delivery systemsSolubilityTargetedLocal administration

Wen Chen、Kun Shi、Yan Yu、Peipei Yang、Zhongwu Bei、Dong Mo、Liping Yuan、Meng Pan、Yu Chen、Zhiyong Qian

展开 >

Department of Biotherapy,Cancer Center and State Key Laboratory of Biotherapy,West China Hospital,Sichuan University,Chengdu 610041,China

国家自然科学基金国家自然科学基金国家自然科学基金四川省科技计划四川省科技计划1.3.5 project for disciplines of excellence,West China Hospital,Sichuan UniversityPost-Doctor Research Project,West China Hospital,Sichuan University

U21A2041731930067318007972022YFS03332022YFS0203ZYGD180022018HXBH066

2024

10.1016/j.cclet.2023.109159

中国化学快报(英文版)
中国化学会

中国化学快报(英文版)

CSTPCD
影响因子：0.771
ISSN：1001-8417
年,卷(期)：2024.35(2)
  • 209