Abstract
Colorectal cancer causes the third most common type of malignant tumors with high morbidity and mor-tality.Chemotherapy is currently one of the most effective and common treatments for colorectal cancer.However,the poor water solubility of some chemotherapeutics,untargeted drug delivery,and the un-desirable systemic side effects of conventional treatment remain the major issues for colorectal cancer chemotherapy.Fortunately,drug delivery systems(DDS)based on biomaterials have been widely investi-gated and found to be capable of resolving those issues with good performance.Therefore,the main goal of this review is to summarize and discuss the progress and potential advantages of different DDS for colorectal cancer chemotherapy.We not only reviewed the nanocarriers used to improve the solubility of chemotherapeutics,including liposomes,micelles,and nanoparticles,but also discussed targeted DDS based on specific ligand-receptor recognition and tumor microenvironmental stimulus responses.Further-more,locally administered systems based on hydrogels and microspheres,which have been shown to increase drug accumulation at the tumor site while decreasing systemic toxicity,were also emphasized.DDS provides a good option for improving the efficacy of chemotherapy in the treatment of colorectal cancer.
基金项目
国家自然科学基金(U21A20417)
国家自然科学基金(31930067)
国家自然科学基金(31800797)
四川省科技计划(2022YFS0333)
四川省科技计划(2022YFS0203)
1.3.5 project for disciplines of excellence,West China Hospital,Sichuan University(ZYGD18002)
Post-Doctor Research Project,West China Hospital,Sichuan University(2018HXBH066)
维普
万方数据