首页|Hybridization chain reaction-based DNA nanomaterials for biosensing,bioimaging and therapeutics
Hybridization chain reaction-based DNA nanomaterials for biosensing,bioimaging and therapeutics
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DNA nanomaterials hold great promise in biomedical fields due to its excellent sequence programma-bility,molecular recognition ability and biocompatibility.Hybridization chain reaction(HCR)is a sim-ple and efficient isothermal enzyme-free amplification strategy of DNA,generating nicked double helices with repeated units.Through the design of HCR hairpins,multiple nanomaterials with desired functions are assembled by DNA,exhibiting great potential in biomedical applications.Herein,the recent progress of HCR-based DNA nanomaterials for biosensing,bioimaging and therapeutics are summarized.Repre-sentative works are exemplified to demonstrate how HCR-based DNA nanomaterials are designed and constructed.The challenges and prospects of the development of HCR-based DNA nanomaterials are dis-cussed.We envision that rationally designing HCR-based DNA nanomaterials will facilitate the develop-ment of biomedical applications.
DNA nanotechnologyHybridization chain reactionDNA nanomaterialsBiosensingBioimagingTherapeutics
Zhaoyue Lv、Mengxue Huang、Peiran Li、Mengdi Xu、Chi Yao、Dayong Yang
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Frontiers Science Center for Synthetic Biology,Key Laboratory of Systems Bioengineering(MOE),Institute of Biomolecular and Biomedical Engineering,School of Chemical Engineering and Technology,Tianjin University,Tianjin 300350,China
Zhejiang Institute of Tianjin University,Ningbo 315201,China
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