首页|A nanoagent for concurrent therapy of breast cancer bone metastasis and cancer-induced bone pain through SLC7A11 interruption and photodynamic therapy

A nanoagent for concurrent therapy of breast cancer bone metastasis and cancer-induced bone pain through SLC7A11 interruption and photodynamic therapy

扫码查看
原文链接
  • 万方数据
  • 维普
Bone metastasis,a life-threatening complication of advanced breast cancer,is often accompanied by debilitating pain(cancer-induced bone pain,CIBP)that severely impairs life quality and survival.The concurrent treatment of bone metastases and CIBP remains a clinical challenge because the therapeu-tic options are limited.In this study,we construct a near-infrared light-activated nano-therapeutic sys-tem to meet this conundrum.In detail,sorafenib(SRF)and photosensitizer(chlorin e6,Ce6)are encap-sulated into mesoporous hydroxyapatite nanoparticles(HANPs),which are further functionalized with hyaluronic acid(HA)to obtain HA-SRF/Ce6@HANPs system.The designed nanoplatform destroys tumor cells in vitro and in vivo via the synergism of SRF(interrupting the exchange of cystine/glutamate by inhibiting SLC7A11)and photodynamic therapy(PDT,inducing reactive oxygen species generation).The decrease in tumor burden and reduction of extracellular glutamate significantly attenuate CIBP in mice model with developing bone cancer.Moreover,the combination of HA-SRF/Ce6@HANPs and PDT inhibit osteoclasts activation,promote osteoblast differentiation and accelerate bone repair.Overall,the nanoa-gent with good biocompatibility may provide an effective therapy method for the concurrent treatment of breast cancer bone metastasis and CIBP.

Breast cancer bone metastasisCancer-induced bone painCystine/glutamate antiporterSorafenibPhotodynamic therapy

Qi Fu、Zhongming Lian、Mengya Niu、Yaru Huang、Yanqiu Ai、Long He、Dandan Zhang、Cuixia Zheng、Jian-Jun Yang、Lei Wang、Dandan Tian

展开 >

Department of Anesthesiology,Pain and Perioperative Medicine,The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450001,China

School of Pharmaceutical Sciences,Zhengzhou University,Zhengzhou 450001,China

Translational Medical Center of Huaihe Hospital,Henan University,Kaifeng 475004,China

Key Laboratory of Advanced Drug Preparation Technologies,Ministry of Education,School of Pharmaceutical Sciences,Zhengzhou University,Zhengzhou 450001,China

展开 >

国家自然科学基金Project Tackling of Key Scientific and Technical Problems of Henan Provine

82001189232102311163

2024

10.1016/j.cclet.2023.108506

中国化学快报(英文版)
中国化学会

中国化学快报(英文版)

CSTPCD
影响因子：0.771
ISSN：1001-8417
年,卷(期)：2024.35(2)
  • 35