首页|Tumor-targeted self-assembled micelles reducing PD-L1 expression combined with ICIs to enhance chemo-immunotherapy of TNBC

Tumor-targeted self-assembled micelles reducing PD-L1 expression combined with ICIs to enhance chemo-immunotherapy of TNBC

扫码查看
原文链接
  • 万方数据
  • 维普
Immune checkpoint inhibitors(ICls)therapy targeting programmed cell death ligand 1(PD-L1)and pro-grammed death protein 1(PD-1)had exhibited significant clinical benefits for cancer treatment such as triple negative breast cancer(TNBC).However,the relatively low anti-tumor immune response rate and ICIs drug resistance highlight the necessity of developing ICIs combination therapy strategies to improve the anti-tumor effect of immunotherapy.Herein,the immunomodulator epigallocatechin gallate palmitate(PEGCG)and the immunoadjuvant metformin(MET)self-assembled into tumor-targeted micelles via hy-drogen bond and electrostatic interaction,which encapsulated the therapeutic agents doxorubicin(DOX)-loaded PEGCG-MET micelles(PMD)and combined with ICIs(anti-PD-1 antibody)as therapeutic strategy to reduce the endogenous expression of PD-L1 and improve the tumor immunosuppressive microenvi-ronment.The results presented that PMD integrated chemotherapy and immunotherapy to enhance an-titumor efficacy in vitro and in vivo,compared with DOX or anti-PD-1 antibody for the therapy of TNBC.PMD micelles might be a potential candidate,which could remedy the shortcomings of antibody-based ICIs and provide synergistic effect to enhance the antitumor effects of ICIs in tumor therapy.

ImmunotherapyTumor-targetedSelf-assembled micellesMetforminReducing PD-L1 expressionTNBC

Hongda Zhu、Kai Ma、Rui Ruan、Chaobo Yang、Aqin Yan、Jing Li、Qi Yu、Hongmei Sun、Mingxing Liu、Hongmei Zheng、Jing Gao、Xiaofang Guan、Zhu Dai、Yao Sun

展开 >

Cooperative Innovation Center of Industrial Fermentation(Ministry of Education & Hubei Province),Key Laboratory of Fermentation Engineering(Ministry of Education),National"111"Center for Cellular Regulation and Molecular Pharmaceutics,School of Food and Biological Engineering,Hubei University of Technology,Wuhan 430068,China

Hubei Cancer Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430079,China

National Key Laboratory of Green Pesticide,College of Chemistry,Central China Normal University,Wuhan 430079,China

Key Laboratory of Medical Optics,Suzhou Institute of Biomedical Engineering and Technology,Chinese Academy of Sciences,Suzhou 215163,China

Key Laboratory of Optic-electric Sensing and Analytical Chemistry for Life Science,Ministry of Education,Qingdao University of Science and Technology,Qingdao 266000,China

展开 >

projects of the National Key Research and Development Program国家自然科学基金国家自然科学基金国家自然科学基金Green Industry Science and Technology Leading Project of Hubei University of Technology湖北省自然科学基金Chinese Society of Clinical Oncology(CSCO)supported by Jiangsu Hengrui Cancer Research Foundation中央高校基本科研业务费专项Opening Fund from the Jiangsu Key Laboratory of Medical Optics,Suzhou Institute of Biomedical Engineering and TechnologyKey Laboratory of Opticelectric Sensing and Analytical Chemistry for Life Science,MO

2021YFA0716702618051222202240422074050XJ20210033012022CFA033YHR2019-0325CCNU22QN007JKLMO202203M2022-5

2024

10.1016/j.cclet.2023.108536

中国化学快报(英文版)
中国化学会

中国化学快报(英文版)

CSTPCD
影响因子：0.771
ISSN：1001-8417
年,卷(期)：2024.35(2)
  • 46