Free amino group-directed C(sp2)-H arylation of α-amino-β-aryl esters by palladium catalysis
Yue Gao 1Yu Du 1Weiping Su1
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作者信息
1. State Key Laboratory of Structural Chemistry,Fujian Institute of Research on the Structure of Matter,Chinese Academy of Sciences,Fuzhou 350002,China;Fujian Science & Technology Innovation Laboratory for Optoelectronic Information of China,Fuzhou 350108,China;University of Chinese Academy of Sciences,Beijing 100049,China
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Abstract
Native amino-directed palladium-catalyzed C(sp3)-H activation/functionalization has been developed for modification of α-amino acids and peptides.Herein a palladium(Ⅱ)-catalyzed C(sp2)-H arylation of α-amino-β-aryl esters has been disclosed,using the native amino as the directing group.A variety of chiralα-amino-β-aryl esters can be functionalized to give the corresponding ortho-substituted mono-and di-arylated products.
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