Free amino group-directed C(sp2)-H arylation of α-amino-β-aryl esters by palladium catalysis

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外文摘要：Native amino-directed palladium-catalyzed C(sp3)-H activation/functionalization has been developed for modification of α-amino acids and peptides.Herein a palladium(Ⅱ)-catalyzed C(sp2)-H arylation of α-amino-β-aryl esters has been disclosed,using the native amino as the directing group.A variety of chiralα-amino-β-aryl esters can be functionalized to give the corresponding ortho-substituted mono-and di-arylated products.

外文关键词：

Native amino-directedPalladium catalystC(sp2)-H arylationα-Amino-β-aryl esterChiral α-amino acid

作者：

Yue Gao、Yu Du、Weiping Su

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作者单位：

State Key Laboratory of Structural Chemistry,Fujian Institute of Research on the Structure of Matter,Chinese Academy of Sciences,Fuzhou 350002,China

Fujian Science & Technology Innovation Laboratory for Optoelectronic Information of China,Fuzhou 350108,China

University of Chinese Academy of Sciences,Beijing 100049,China

基金：

国家重点研发计划国家自然科学基金国家自然科学基金Fujian Science and Technology Innovation Laboratory for Optoelectronic Information of China

项目编号：

2018YFA070450221871261219310112021ZZ105

出版年：

2024

DOI：

10.1016/j.cclet.2023.108505

中国化学快报(英文版)

中国化学会

中国化学快报(英文版)

CSTPCD

影响因子：0.771

ISSN：1001-8417

年,卷(期)：2024.35(2)

参考文献量34