β-C(sp3)-H chlorination of amide derivatives via photoinduced copper charge transfer catalysis

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外文摘要：An atom economic β-C(sp3)-H chlorination of amide derivatives has been developed.This mild protocol employs CuCl2 instead of palladium catalysts with atom-economic HCl as chlorine sources and enables the late-stage functionalization of medicine derivatives.Mechanism studies suggest a plausible visible light triggered ligand-to-metal charge transfer(LMCT)/1,4-hydrogen atom transfer(HAT)cascade.

外文关键词：

Photoinduced copper catalysisLigand-to-metal charge transfer1,4-Hydrogen atom transferβ-Halogenated amideLate-stage functionalization

作者：

Yuhang He、Chao Tian、Guanghui An、Guangming Li

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作者单位：

Key Laboratory of Functional Inorganic Material Chemistry(MOE),School of Chemistry and Materials Science,Heilongjiang University,Harbin 150080,China

基金：

University Nursing Program for Young Scholars with Creative Talents in Heilongjiang Province

项目编号：

UNPYSCT-2017124

出版年：

2024

DOI：

10.1016/j.cclet.2023.108546

中国化学快报(英文版)

中国化学会

中国化学快报(英文版)

CSTPCD

影响因子：0.771

ISSN：1001-8417

年,卷(期)：2024.35(2)

参考文献量68