β-C(sp3)-H chlorination of amide derivatives via photoinduced copper charge transfer catalysis
Yuhang He 1Chao Tian 1Guanghui An 1Guangming Li1
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作者信息
1. Key Laboratory of Functional Inorganic Material Chemistry(MOE),School of Chemistry and Materials Science,Heilongjiang University,Harbin 150080,China
折叠
Abstract
An atom economic β-C(sp3)-H chlorination of amide derivatives has been developed.This mild protocol employs CuCl2 instead of palladium catalysts with atom-economic HCl as chlorine sources and enables the late-stage functionalization of medicine derivatives.Mechanism studies suggest a plausible visible light triggered ligand-to-metal charge transfer(LMCT)/1,4-hydrogen atom transfer(HAT)cascade.
Key words
Photoinduced copper catalysis/Ligand-to-metal charge transfer/1,4-Hydrogen atom transfer/β-Halogenated amide/Late-stage functionalization
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基金项目
University Nursing Program for Young Scholars with Creative Talents in Heilongjiang Province(UNPYSCT-2017124)
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