Photo-induced 1,2-aryl migration of 2-chloro-1-arylpropanone under batch and flow conditions:Rapid,scalable and sustainable approach to 2-arylpropionic acids

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外文摘要：We report the photo-mediated 1,2-aryl migration of 2-chloro-1-arylpropanones to 2-arylpropionic acids using HCOONa as an acid scavenger.This pragmatically focused study obviates the multiple-step sequence in the industrially employed,ZnO-promoted rearrangement strategy,and offers rapid access to various 2-arylpropionic acids under environmentally friendly conditions.Furthermore,the successful transfer of this batch photochemistry to a continuous flow platform led to improved scalability and enabled the gram-scale synthesis of loxoprofen.

外文关键词：

Green chemistryFlow chemistry2-Arylpropionic acidsPhoto-Favorskii reaction

作者：

Qiao Li、Minjie Liu、Meifen Jiang、Li Wan、Yingtang Ning、Fen-Er Chen

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作者单位：

College of Chemical Engineering,Zhejiang University of Technology,Hangzhou 310014,China

Engineering Center of Catalysis and Synthesis for Chiral Molecules,Fudan University,Shanghai 200433,China

Shanghai Engineering Center of Industrial Catalysis for Chiral Drugs,Shanghai 200433,China

Institute of Pharmaceutical Science and Technology,Zhejiang University of Technology,Hangzhou 310014,China

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基金：

国家自然科学基金

项目编号：

22077018

出版年：

2024

DOI：

10.1016/j.cclet.2023.108576

中国化学快报(英文版)

中国化学会

中国化学快报(英文版)

CSTPCD

影响因子：0.771

ISSN：1001-8417

年,卷(期)：2024.35(2)

参考文献量51