Abstract
Microfluidic combined with magnetic field have been demonstrated to be the promising solutions for fast and low-damage particles separation.However,the difficulties in the precise layout of magnets and accurate prediction of particle trajectories lead to under and over separation of target particles.A novel particle separation lab-on-chip(LOC)prototype integrated with microstructures and micropolar arrays is designed and characterized.Meanwhile,a numerical model for the separation of magnetic particles by the synergistic effect of geometry-induced hydrodynamics and magnetic field is constructed.The effect of geometry and magnetic field layout on particle deflection is systematically analyzed to implement ac-curate prediction of particle trajectories.It is found that the separation efficiency of magnetic particles increased from 50.2％to 91.7％and decreased from 88.6％to 85.7％in the range of depth factors from 15 μm to 27 μm and width factors from 30 μm to 60 μm,respectively.In particular,the combined effect of the offset distance of permanent magnets and the distance from the main flow channel exhibits a significant difference from the conventional perception.Finally,the developed LOC prototype was gener-alized for extension to arbitrary systems.This work provides a new insight and robust method for the microfluidic separation of magnetic particles.
基金项目
国家自然科学基金(11502044)
国家自然科学基金(U1906233)
中央高校基本科研业务费专项(DUT22JC08)
Liaoning Province's Xing Liao Talents Program(XLYC2002108)
Dalian City Supports Innovation and Entrepreneurship Projects for High-level Talents(2021RD16)
维普
万方数据