首页|Microfluidic separation of particles by synergistic effect of geometry-induced hydrodynamics and magnetic field

Microfluidic separation of particles by synergistic effect of geometry-induced hydrodynamics and magnetic field

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Microfluidic combined with magnetic field have been demonstrated to be the promising solutions for fast and low-damage particles separation.However,the difficulties in the precise layout of magnets and accurate prediction of particle trajectories lead to under and over separation of target particles.A novel particle separation lab-on-chip(LOC)prototype integrated with microstructures and micropolar arrays is designed and characterized.Meanwhile,a numerical model for the separation of magnetic particles by the synergistic effect of geometry-induced hydrodynamics and magnetic field is constructed.The effect of geometry and magnetic field layout on particle deflection is systematically analyzed to implement ac-curate prediction of particle trajectories.It is found that the separation efficiency of magnetic particles increased from 50.2％to 91.7％and decreased from 88.6％to 85.7％in the range of depth factors from 15 μm to 27 μm and width factors from 30 μm to 60 μm,respectively.In particular,the combined effect of the offset distance of permanent magnets and the distance from the main flow channel exhibits a significant difference from the conventional perception.Finally,the developed LOC prototype was gener-alized for extension to arbitrary systems.This work provides a new insight and robust method for the microfluidic separation of magnetic particles.

MicrofluidicParticle separationSynergistic effectHydrodynamicsMagnetic fieldNumerical calculation

Du Qiao、Hongxia Li、Weiping Zhu、Lili Zhu、Danyang Zhao、Honglin Li

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Key Laboratory for Precision & Non-traditional Machining Technology of Ministry of Education,Dalian University of Technology,Dalian 116023,China

Shanghai Key Laboratory of New Drug Design,School of Pharmacy,East China University of Science and Technology,Shanghai 200237,China

Lingang Lab,Shanghai 200031,China

国家自然科学基金国家自然科学基金中央高校基本科研业务费专项Liaoning Province's Xing Liao Talents ProgramDalian City Supports Innovation and Entrepreneurship Projects for High-level Talents

11502044U1906233DUT22JC08XLYC20021082021RD16

2024

10.1016/j.cclet.2023.108646

中国化学快报(英文版)
中国化学会

中国化学快报(英文版)

CSTPCD
影响因子：0.771
ISSN：1001-8417
年,卷(期)：2024.35(2)
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