首页|A coating strategy on titanium implants with enhanced photodynamic therapy and CO-based gas therapy for bacterial killing and inflammation regulation

A coating strategy on titanium implants with enhanced photodynamic therapy and CO-based gas therapy for bacterial killing and inflammation regulation

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Antimicrobial photodynamic therapy(aPDT)has been considered a noninvasive and effective modality against the bacterial infection of peri-implantitis,especially the aPDT triggered by near-infrared(NIR)light due to the large penetration depth in tissue.However,the complexity of hypoxia microenviron-ments and the distance of aPDT sterilization still pose challenges before realizing the aPDT clinical ap-plication.Due to the long lifespan and transmission distance of therapeutic gas molecules,we design a multi-functional gas generator that combines aPDT as well as O2 and CO gas release function,which can solve the problem of hypoxia(O2)in PDT and the problem of inflammation regulation(CO)in the distal part of peri-implant inflammation under near-infrared(NIR)irradiation.In the composite nanoplatform that spin-coated on the surface of titanium implants,up-conversion nanoparticles(UCNPs)were involved in converting the NIR to visible,which further excites the partially oxidized stannic sulfide(SnS2),real-izing the therapeutic gas release.Indocyanine green(ICG)was further integrated to enhance the aPDT performance(Ti-U@SnS2/I).Therefore,reactive oxygen species(ROS),CO,and O2 can be controllably ad-ministered via a composite nano-platform mediated by a single NIR light(808 nm).This implant surface modification strategy could achieve great self-enhancement antibacterial effectiveness and regulate the lingering questions,such as relieving the anoxic microenvironment and reaching deep infection sites,providing a viable antibiotic-free technique to combat peri-implantitis.

Photodynamic therapyBiomaterialsDental implantReactive oxygen speciesCarbon monoxideHybrid nanoplatform

Liang Cheng、Bingshuai Zhou、Manlin Qi、Xiaolin Sun、Shujun Dong、Yue Sun、Biao Dong、Lin Wang、Yingwei Yang

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Department of Oral Implantology,Jilin Provincial Key Laboratory of Sciences and Technology for Stomatology Nanoengineering School and Hospital of Stomatology,Jilin University,Changchun 130021,China

State Key Laboratory on Integrated Optoelectronics,College of Electronic Science and Engineering,Jilin University,Changchun 130021,China

College of Chemistry,Jilin University,Changchun 130012,China

国家自然科学基金国家自然科学基金国家自然科学基金中国博士后科学基金General program of the Natural Science Foundation of Jilin ProvinceGeneral program of the Natural Science Foundation of Jilin ProvinceGeneral program of the Natural Science Foundation of Jilin ProvinceGeneral program of the Natural Science Foundation of Jilin ProvinceGeneral program of the Natural Science Foundation of Jilin ProvinceHygiene and Health Appropriate Technology Promotion Project of Jilin ProvinceScience and Technology Project of Jilin Province Financial DepartmentScience and Technology Project of Jilin Province Financial DepartmentScience and Technology Project of Jilin Province Financial DepartmentScience and Technology Project of Jilin Province Education DepartmentHealth Department Research Projects of Jilin Province

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2024

10.1016/j.cclet.2023.108648

中国化学快报(英文版)
中国化学会

中国化学快报(英文版)

CSTPCD
影响因子：0.771
ISSN：1001-8417
年,卷(期)：2024.35(2)
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