Deoximation is an important transformation in synthetic industry.It can be employed in protection,characterization and purification of the carbonyls,and in the synthesis of ketones from non-carbonyl molecules.In the field,oxidative deoximation reaction can utilize the driving force caused by the oxida-tion process so that the reaction can occur under relatively mild conditions.Recently,we designed and prepared polyaniline-supported molybdenum(Mo@PANI)just by immersing PANI into the EtOH/H2O so-lution of MoCl5.The material was successfully applied as the efficient catalyst for oxidative deoximation reactions,which were performed in ethanol using H2O2 as the clean oxidant.The substrate scope of the reaction was wide.It could be applied on heterocycle-containing substrates,making this protocol prefer-able for pharmaceutical intermediate synthesis.Since Mo is a necessary trace element for both animals and plants,this method is environment-friendly and is suitable for large-scale preparation.This work as the first example of Mo-catalyzed oxidative deoximation reaction may inspire novel ideas for both cata-lyst design and synthetic process development.
MolybdenumPolyanilineOxidationDeoximationCarbonyl
Yiyang Zhang、Wen Li、Zuofeng Hu、Xiaobi Jing、Lei Yu
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School of Mechanical Engineering,Yangzhou University,Yangzhou 225127,China
School of Chemistry and Chemical Engineering,Yangzhou University,Yangzhou 225002,China
Yangzhou Yangzi Auto Interior & Exterior Co.,Ltd.,Yangzhou 225119,China
江苏高校优势学科建设工程项目fund of the jointlaboratory of Shanghai Dingya Pharmaceutical Chemical Technology Co.,Ltd.with Yangzhou University
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