Abstract
Bridged polycyclic lactams are important structural units in organic functional materials,natural products,and pharmaceuticals.A flexible and efficient anion cascade reaction was developed for the preparation of bridged polycyclic lactams from readily available malonamides and 1,4-dien-3-ones.Various highly sub-stituted bridged polycyclic lactams were synthesized in good to excellent yields by tandem nucleophilic sequences in the presence of tBuOK in commercially available EtOH solvent at 60 ℃.Notably,the simple reactions can be run on a gram scale.Mechanistically,bis-Michael addition reaction and hemiaminaliza-tion reactions are involved in the tandem transformation.
基金项目
国家自然科学基金(21772032)
国家自然科学基金(21877206)
国家自然科学基金(22101074)
高等学校学科创新引智计划(111计划)(D17007)
Excellent Youth Foundation of Henan Scientific Committee(222300420012)
中国博士后科学基金(2019M660173)
河南省自然科学基金(202300410233)
Henan Key Laboratory of Organic Functional Molecules and Drug Innovation()
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