首页|Chemoselective electrochemical seleno-cyclization of dienes to medium-sized benzo[b]azocines
Chemoselective electrochemical seleno-cyclization of dienes to medium-sized benzo[b]azocines
扫码查看
点击上方二维码区域，可以放大扫码查看
原文链接
万方数据
维普
The preparation of medium-sized benzo[b]azocines has always been challenging because of inher-ently unfavorable enthalpy and entropy factors.This report presents a novel approach for accessing 8-membered seleno-benzo[b]azocines via electrochemically-driven seleno-cyclization.This method enables room-temperature preparation of various structurally diverse medium-sized seleno-benzo[b]azocines.The facile deselenation of the seleno-cyclization products to generate functionalized dienes is an additional benefit of this indispensable reaction.Mechanistic insights are presented based on radical inhibition ex-periments and cyclic voltammetry measurements,which elucidate the radical pathway.Finally,density functional theory calculations further rationalize the rate-determining step and the unique chemoselec-tivity observed in this transformation.
Zhichuan Wang、Xin Wang、Quanxin Li、Shaofei Ni、Dongyang Zhao、Shubin Yang、Ge Qiu、Kai Sun
展开 >
College of Chemistry and Chemical Engineering,Yantai University,Yantai 264005,China
Department of Chemistry and Key Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong Province,Shantou University,Shantou 515063,China
万方数据
维普
